# Administrative Core

> **NIH NIH P30** · UNIVERSITY OF MARYLAND BALTIMORE · 2020 · $123,782

## Abstract

ADMINISTRATIVE CORE ABSTRACT
In the United States, 70% of deaths annually can be attributed to chronic conditions. One of the most frequent
and debilitating is pain, which can either occur as a symptom of chronic illness or as a primary problem.
According to the recent Institute of Medicine (IOM) report on Relieving Pain in America (2011), chronic pain is
a public health epidemic affecting more than 116 million Americans and costing more than $600 billion per year
in healthcare expenses and lost work productivity—despite advances in pharmacological treatment, most
people do not obtain adequate pain relief. Recently, various types of self-management strategies have been
tested for chronic pain management, including cognitive behavioral therapy (CBT), non-pharmacologic
treatments (e.g., heat, cold, acupuncture, etc.) and physical activity. However, much like pharmacogenomic
influences on individual response to drug treatment, self-management intervention trials have demonstrated
mixed results in that some, but not all, study participants respond or participate. This could be due to many
factors, including resilience, motivation and/or capability. Moreover, the omics mechanisms underlying the
relative success or failure of self-management interventions on an individual level have been understudied.
Guided by an adapted National Institutes of Health Symptom Science (NIHSS) model, we propose to develop
the University of Maryland, Baltimore (UMB) Omics Associated with Self-management Interventions for
Symptoms (OASIS) Center. The science of this Center will focus on our hypothesis that genomic,
transcriptomic, epigenomic, and proteomic outcomes (hereafter referred to as “omics”), mediated by
psychosocial factors and sex differences and/or moderated by the environment, predict individual resilience,
motivation, and capability to engage in and participate in self-management behaviors (physical activity) and
response to interventions designed to improve chronic pain. The Administrative Core (AC) of the OASIS
Center will provide the structure and fiscal resources necessary to ensure successful management of overall
Center activities including the development, promotion, and fiscally responsible management of Center
resources. We will accomplish this goal via the successful accomplishment of four specific aims including (1)
Provide strategic oversight and coordination of all administrative functions of OASIS, including data sharing,
review of funds utilization by the Cores and Pilot PIs to ensure that funds are appropriately expended, and
development of effective and efficient communication plans to enhance collaboration, (2) Optimize and
enhance Core resource utilization on the UMB campus, across the University of Maryland System (USM) and
with external university partners, (3) Capitalize on new infrastructure supports provided by OASIS, internal and
external collaborations, and successful completion of innovative, cutting edge pilot studies, to ensure lon...

## Key facts

- **NIH application ID:** 9940786
- **Project number:** 5P30NR016579-05
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** SUSAN G DORSEY
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $123,782
- **Award type:** 5
- **Project period:** — → 2022-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9940786

## Citation

> US National Institutes of Health, RePORTER application 9940786, Administrative Core (5P30NR016579-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9940786. Licensed CC0.

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