# HPV Capsid Antibodies

> **NIH NIH R01** · FRED HUTCHINSON CANCER RESEARCH CENTER · 2020 · $480,737

## Abstract

Summary
Human papillomaviruses (HPV) are the most common sexually transmitted infection in the US. Upon infection
individuals make a low-titer antibody response to conformational epitopes on the L1 protein. Most HPV
infections are controlled or cleared, however in some individuals infection can persist and give rise to
neoplastic lesions. Highly efficacious vaccines are in widespread use to prevent human papillomavirus (HPV)
disease. Our previous studies have focused on polyclonal antibody responses in subjects who were naturally
infected or who had been vaccinated. Given new approaches that we have developed, we now have the ability
to more fully characterize the B cell memory repertoire, including plasmablasts (PB), B memory cells (Bmem)
and human monoclonal antibodies isolated from Bmem and PB. We will study the basis of antibodies
neutralizing activity as well as other possible mechanisms of protection. It is an important goal to determine the
signatures that may be associated with long term protection of a vaccine given to adolescents or pre-
adolescents that will need protection for several decades. The efficacy trials of HPV vaccines have all
delivered three doses of vaccine but there is considerable interest in switching to two or fewer doses. We will
examine the B cell memory responses obtained from an ongoing trial comparing two doses vs three doses of
the new nine-valent HPV vaccine.

## Key facts

- **NIH application ID:** 9941049
- **Project number:** 5R01AI038382-26
- **Recipient organization:** FRED HUTCHINSON CANCER RESEARCH CENTER
- **Principal Investigator:** DENISE A. GALLOWAY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $480,737
- **Award type:** 5
- **Project period:** 1995-05-15 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9941049

## Citation

> US National Institutes of Health, RePORTER application 9941049, HPV Capsid Antibodies (5R01AI038382-26). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/9941049. Licensed CC0.

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