# Neuropathological changes underlying clinical heterogeneity in Alzheimer disease

> **NIH NIH K24** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $164,900

## Abstract

ABSTRACT
This is an application for a K24 award for Dr. Lea T. Grinberg, a neuropathologist at the University of
California, San Francisco (UCSF). Dr. Grinberg is an Associate Professor in Residence and co-lead the
UCSF/Memory and Aging Center's Neuropathology Core. She is an established researcher in the patient-
oriented clinical research of dementia. A distinctive hallmark of her research is her direct involvement in
creating, managing and analyzing well-characterized postmortem collections of brains belonging to people at-
risk or already with dementia. Dr. Grinberg proposes to use K24 dedicated time to mentor USCF as well as
international investigators in patient-oriented dementia research. Her mentees will gain hands-on research
experience, expertise in age-related human neuropathology, training in data analysis, manuscript preparation,
and grant writing, as well as career, mentoring. Mentee training will leverage the infrastructure and resources
of the UCSF/Memory and Aging Center Autopsy program, which is part of ongoing longitudinal cohort studies
(P50AG02350 and P01AG019724), and her collaborations with multidisciplinary researchers in the areas of
dementia domestically and worldwide. To increase her mentoring skills, she proposes to participate in the
UCSF Mentor Development Program. Dr. Grinberg intends to conduct K24-supported Alzheimer's disease
research studies that will serve as training vehicles for mentees and expand her research. These studies,
using clinical, genetic and neuropathological data, will be conducted using data from ongoing UCSF/Memory
and Aging Center's NIH-funded cohort studies of persons with Alzheimer's disease(AD) . She will examine the
role of recently described neurodegenerative changes in modifying the clinical phenotype of AD. In summary,
this K24 will enhance Dr. Ginberg's active research program with extensive infrastructure at UCSF to support
her goal to remain a leader in neurodegenerative diseases, especially in the field of neuropathology, and to
develop a program of excellence for training medical students, trainees, and junior faculty in POR related to
age-related neuropathology that is also intended to close the gaps caused by interruption of neuropathology
training for neurologists and neurodegenerative disease training for neuropathologists.

## Key facts

- **NIH application ID:** 9942352
- **Project number:** 5K24AG053435-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Lea Tenenholz Grinberg
- **Activity code:** K24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $164,900
- **Award type:** 5
- **Project period:** 2016-08-15 → 2021-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9942352

## Citation

> US National Institutes of Health, RePORTER application 9942352, Neuropathological changes underlying clinical heterogeneity in Alzheimer disease (5K24AG053435-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9942352. Licensed CC0.

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