# Disruption of T cell tolerance in type 1 diabetes

> **NIH NIH P01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $1,570,677

## Abstract

Project Summary/Abstract
Autoimmune diseases like type 1 diabetes arise through a breakdown in immune tolerance. We have now
come to understand that immune tolerance consists of a multi-layered network that keeps such untoward
responses in check. In this program project grant, three complementary teams will be working together to
further unravel how these checkpoints operate to improve our understanding of autoimmunity and ultimately
improve its treatment. This program project will have three highly collaborative and interactive projects headed
by Drs. Mark Anderson (Project 1), Jeff Bluestone (Project 2) and John Kappler (Project 3) along with two
scientific cores (Animal core and Molecular core). The major themes of the grant are:
1. The impact of central thymic tolerance on the T effector and Treg repertoire in T1D..
2. Insulin as a critical self-antigen specificity for both T effectors and T regulatory cells in T1D.
3. Peptide specificity of Tregulatory cells in T1D
4. Using peptide binding characteristics of islet antigens to improve bioassays and tolerance methods.
The long term objectives of this work is to improve our understanding of how T cell tolerance is controlled and
the further refining the specificity of the autoreactive T cell response in type 1 diabetes. The investigators will
be using state of the art tools in both animal models and in human subjects with type 1 diabetes. Results of
these studies will help further refine our understanding of autoimmunity and help improve methods for its
treatment and diagnosis.

## Key facts

- **NIH application ID:** 9942357
- **Project number:** 5P01AI118688-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Mark S Anderson
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,570,677
- **Award type:** 5
- **Project period:** 2016-06-08 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9942357

## Citation

> US National Institutes of Health, RePORTER application 9942357, Disruption of T cell tolerance in type 1 diabetes (5P01AI118688-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9942357. Licensed CC0.

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