# Core A - Animal core

> **NIH NIH P01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $230,368

## Abstract

Project Summary/Abstract 
The use of genetically altered mice has revolutionized the study of many complex biological processes 
including immune tolerance and autoimmunity. This is clearly reflected in all the projects in this PPG, which 
rely heavily on the use of transgenic, knockout, and autoimmune-prone mouse strains. A mouse Core is 
envisioned that will help streamline and improve efficiencies with the generation and maintenance of 
genetically complex lines in a healthy, pathogen-free environment. 
The specific aims of this Core are: 
1. To breed and genetically characterize unique and non-routine mouse strains for use by all of the program 
project members. 
2. To assist program project members with routine backcrossing of newly obtained or derived strains to the 
appropriate genetic backgrounds for planned studies 
3. To ensure animals provided to program project members are healthy and maintained in a pathogen-free 
environment for the proposed studies. 
The availability of the Core ensures that the PPG investigators will be able to obtain healthy and pathogen-free 
animals of complex genetic make-up for use in the proposed studies.

## Key facts

- **NIH application ID:** 9942368
- **Project number:** 5P01AI118688-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Mark S Anderson
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $230,368
- **Award type:** 5
- **Project period:** — → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9942368

## Citation

> US National Institutes of Health, RePORTER application 9942368, Core A - Animal core (5P01AI118688-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9942368. Licensed CC0.

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