# Role of the Long Non-coding RNA PVT1 in Cancer

> **NIH NIH R01** · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · 2020 · $446,063

## Abstract

Abstract
Here we propose that a long non-coding RNA PVT1 can provide a solution for developing effective therapy
against multiple human cancers. We have recently identified the mechanistic basis of 8q24 amplification, one
of the most common mutations present in almost all kinds of cancer. We have identified a long noncoding
RNA, PVT1, which is a part of the 8q24 amplicon, as a major oncogene. We have found that PVT1 can
regulate the stability of MYC, one of the most important drivers in cancer. We hypothesize that the dependence
of MYC on PVT1 can be exploited to target MYC, otherwise a notoriously undruggable candidate. In this
proposal we propose to dissect the mechanism through which PVT1 regulates MYC protein levels in cancer.
We also investigate the role of PVT1 in cancers without supernumerary 8q4. Finally, we will examine the
therapeutic potential of PVT1 specific antisense oligonucleotides in vivo and in xenograft models. We propose
that our new findings will enable the cancer community to develop new therapeutic strategies for cancer
patients in near future.

## Key facts

- **NIH application ID:** 9942387
- **Project number:** 5R01CA200643-05
- **Recipient organization:** SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- **Principal Investigator:** Anindya Bagchi
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $446,063
- **Award type:** 5
- **Project period:** 2017-07-01 → 2021-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9942387

## Citation

> US National Institutes of Health, RePORTER application 9942387, Role of the Long Non-coding RNA PVT1 in Cancer (5R01CA200643-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9942387. Licensed CC0.

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