# Additional Sequencing for the Alzheimer's Disease Sequencing Project (ADSP)

> **NIH NIH U01** · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2020 · $4,271,716

## Abstract

PROJECT SUMMARY
Alzheimer disease (AD) is the leading cause of dementia in the elderly and occurs in all ethnic and racial groups.
A multitude of genetic studies in AD have identified multiple AD associated genes and loci, but a large portion of
the genetic contribution to AD remains unknown. The Alzheimer Disease Sequencing Project (ADSP) is using
large-scale sequencing efforts to increase our knowledge about the genetic variation that influences AD,
particularly rare genetic variants that enhance AD risk or protect against AD. In the most recent wave of funding,
the ADSP is sequencing individuals from the ADSP Follow-up Study (FUS) through AG057659 and AG062943.
These efforts were specifically designed to improve racial and ethnic diversity in the ADSP datasets as well as
to acquire unique and powerful data sets for gene discovery in NHW individuals, such as the Amish protective
variant (AMISHPV) dataset, several large autopsy-confirmed series and the ADGC's early-onset AD dataset.
The purpose of these studies has been to capitalize on differences in genetic backgrounds that may facilitate
the identification of new protective and risk loci and ultimately address health disparities for AD and related
disorders in underserved populations. Including the cohorts in this application, the ADSP-FUS will perform WGS
on nearly 30,000 individuals. An added benefit of this application is the processing and delivery of high quality
WGS and phenotype data on the new cohorts in this application. Specifically we propose to: (1) Increase the
diversity and further enrich the clinical phenotype data of the ADSP through inclusion of ~1900 AD cases and
controls from the Alzheimer Disease Center (ADC) Hispanic cohort, ~1500 AD cases and controls from the Faroe
Islands, and ~3,200 AD cases and controls from the well characterized ethnically diverse A4 Clinical Trial Cohort;
(2) work closely with the National Cell Repository for Alzheimer's Disease (NCRAD) in assembling DNA and
blood on these existing cohorts which will ultimately serve as a central resource for the Alzheimer's disease
research community; (3) generate genome-wide SNP array data and WGS data for all collected samples using
established resources; (4) collaborate with NIAGADS, GCAD and the HIHG CGESG-PGNC QC Teams in
processing, storage, and delivery of final datasets to NIAGADS for public data release; and (5) harmonize clinical
data from newly acquired and existing FUS datasets to generate high quality inferentially equivalent phenotypes
and endophenotypes. This project will merge several new cohorts into the ADSP-FUS to further enhance the
ADSP as an invaluable resource for the Alzheimer's disease (AD) research community. These efforts will speed
discoveries of targets for AD diagnosis, prevention, and treatment for all populations.

## Key facts

- **NIH application ID:** 9945692
- **Project number:** 1U01AG066767-01
- **Recipient organization:** UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- **Principal Investigator:** MICHAEL L CUCCARO
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $4,271,716
- **Award type:** 1
- **Project period:** 2020-07-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9945692

## Citation

> US National Institutes of Health, RePORTER application 9945692, Additional Sequencing for the Alzheimer's Disease Sequencing Project (ADSP) (1U01AG066767-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9945692. Licensed CC0.

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