# Rcor1 Regulates Myelomonocytic Progenitor Cell Fate

> **NIH NIH R01** · OREGON HEALTH & SCIENCE UNIVERSITY · 2020 · $346,500

## Abstract

Project Summary
Understanding the molecular mechanisms that govern hematopoietic lineage specification and
differentiation is critical for developing targeted therapies for bone marrow failure and
myeloproliferative disorders. Rcor1 (CoREST) is an established cofactor for the histone
demethylase LSD1/KDM1, however its role in regulating hematopoiesis is unknown. Using a
conditional knockout model we now demonstrate that myeloerythroid differentiation is
profoundly dependent on Rcor1. The overall goal of this proposal is to the identify the
mechanisms by which Rcor1 regulates myelomonocytic progenitors. Specifically we will i)
Determine the functions of Rcor1 in myelomonocytic progenitors and monocytes; ii) Identify
Rcor1 targets in granulocyte precursors and monocytes and iii) Determine the functions of the
Rcor1 target genes and pathways in myelomonocytic progenitor cell differentiation. By profiling
the transcriptional programs in Rcor1 deficient progenitors, we will identify functionally relevant
transcriptional targets of Rcor1. The results of this study will contribute to our understanding of
epigenetic regulation of normal hematopoietic progenitor cells and will likely provide important
insights relevant to the pathogenesis of bone marrow failure syndromes and myeloproliferative
disorders.

## Key facts

- **NIH application ID:** 9947926
- **Project number:** 5R01DK109694-05
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** WILLIAM H FLEMING
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $346,500
- **Award type:** 5
- **Project period:** 2016-07-15 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9947926

## Citation

> US National Institutes of Health, RePORTER application 9947926, Rcor1 Regulates Myelomonocytic Progenitor Cell Fate (5R01DK109694-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9947926. Licensed CC0.

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