# Structural Biological Studies of Thipeptide Biosynthesis and Engineering

> **NIH NIH R01** · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2020 · $301,898

## Abstract

Thiazolyl peptides are natural products with a wide range of biological activities,
including anticancer, antiplasmodial, and antibacterial. Although the natural compounds
are not suitable drug because of poor solubility, many synthetic derivatives are currently
in clinical trials. An understanding of the enzymes that convert peptide substrates into
thiazolyl peptides will significantly aid in producing molecules with better drug-like
properties. We seek to carry out biochemical, and structural biological studies on several
of these enzymes to help guide the production of improved versions of these bioactive
compounds.

## Key facts

- **NIH application ID:** 9948699
- **Project number:** 5R01GM131347-02
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- **Principal Investigator:** Satish K Nair
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $301,898
- **Award type:** 5
- **Project period:** 2019-07-01 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9948699

## Citation

> US National Institutes of Health, RePORTER application 9948699, Structural Biological Studies of Thipeptide Biosynthesis and Engineering (5R01GM131347-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9948699. Licensed CC0.

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