# Clinical and Translational Science Institute at Childrens National

> **NIH NIH UL1** · CHILDREN'S RESEARCH INSTITUTE · 2020 · $5,351,164

## Abstract

OVERALL: PROJECT ABSTRACT
Although children comprise one-quarter of the US population, only 10% of ClinicalTrials.gov registered studies
focus on child health-related clinical and translational research (CTR). The mission of the Clinical and
Translational Science Institute at Children's National (CTSI-CN) is to address the barriers and serve as a hub
within the CTSA Network that is focused on the promotion of child health CTR. Established in 2010, the
inaugural CTSI-CN (CTSI-CN v1.0) was organized as a collaboration between Children's National Health
System (CNHS) and its academic partner, The George Washington University (GW). Over the past four years,
CTSI-CN v1.0 has positioned itself as an effective catalyst for child-health CTR around four major themes: 1)
improving the health of children and their families; 2) developing novel treatment strategies for rare genetic
diseases; 3) designing new devices for pediatric care; and 4) characterizing childhood precursors of disease
along the lifespan. We have embraced many of the tenets recommended in the July 2013 Institute of Medicine
(IOM) report, specifically, developing multidisciplinary teams, providing cost-effective services and support for
investigators, and streamlining processes that impact the effective conduct of CTR. The CTSI-CN is
acknowledged locally as the hub for effective, high quality child health CTR and as a nurturing, integrated
home for CTR team science. Nationally, the CTSI-CN has provided leadership in child health CTR, in both
CTSA- and non-CTSA-linked consortia and steering committees. In the current proposal (CTSI-CN v2.0), we
will continue to advance our vision and mission through innovative approaches and enhanced capabilities in
our strategic themes. To this end, we have expanded our partnership to include Virginia Tech (VT) and its
clinical partner, the Carilion Clinic. The goals of CTSI-CN v2.0, which will build on our established strengths,
the lessons learned in CTSI-CN v1.0, and our new partnership with VT/Carilion (VTC), will also address the
four NCATS strategic themes by: 1) developing a new generation of diverse, high quality child health-focused
CTR investigators through innovative, inter-institutional educational, training, and mentoring programs
(WORKFORCE DEVELOPMENT); 2) creating innovative approaches and technologies to catalyze CTR,
particularly in child-health, through novel cross-disciplinary and inter-institutional collaborations with multiple
stakeholder communities (COLLABORATION AND ENGAGEMENT); 3) catalyzing the development,
dissemination and evaluation of novel methods to enhance translational science, with a particular emphasis on
the child-health CTR spectrum (METHODS AND PROCESSES); 4) enhancing quality and efficiency across
the translational spectrum through a) the integration of a high quality diverse workforce, b) implementation of
new methods and processes, and c) collaboration among the institutional partners and communities
(INTEGRATION)...

## Key facts

- **NIH application ID:** 9948780
- **Project number:** 5UL1TR001876-05
- **Recipient organization:** CHILDREN'S RESEARCH INSTITUTE
- **Principal Investigator:** MICHAEL JAMES BELL
- **Activity code:** UL1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $5,351,164
- **Award type:** 5
- **Project period:** 2016-07-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9948780

## Citation

> US National Institutes of Health, RePORTER application 9948780, Clinical and Translational Science Institute at Childrens National (5UL1TR001876-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9948780. Licensed CC0.

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