# Heart Failure in Single Right Ventricle Physiology: Pathologic Mechanisms and Novel Assessment

> **NIH NIH K23** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2020 · $200,772

## Abstract

Project Summary/Abstract
 The most severe form of congenital heart disease includes patients with single right ventricle (SRV)
physiology who exhibit 40% mortality by 5 years of age. These patients are all at very high risk for heart failure.
Clinical drug trials in these patients show that therapies proven to be efficacious in adults do not appear to
improve heart failure in patients with SRV physiology. There exist numerous hypotheses to potentially explain
these differences, all of which revolve around the theoretical differences in cardiac mechanics between
biventricular and single ventricle physiology. However, none of these hypotheses can currently be tested
because 1) the pathophysiologic mechanisms behind the development of heart failure in patients with SRV
have not been comprehensively studied, 2) there are currently no reliable methods to non-invasively assess
cardiac mechanics in patients with SRV, and 3) the associations between these measures and patient
outcomes has not been studied.
 My long term goal is to become an independent scientist in the evaluation of heart failure in patients with
single ventricle physiology so that I may investigate novel heart failure therapies by leading clinical trials in
these patients and use serum/non-invasive heart failure biomarkers to gain insight into the results of such
trials. To reach this goal, complete the following aims: 1) Investigate pathophysiologic mechanisms that lead to
the development of heart failure in patients with SRV, 2) assess the accuracy of echocardiographic measures
of cardiac mechanics by assessing their correlation with reference-standard measures, and 3) investigate the
clinical utility of these serum and non-invasive measures of myocardial function by assessing their association
with short-term outcomes.
 The resultant understanding of SRV physiology will lead to new and innovative therapies, and ideally,
improve outcomes in this vulnerable population. The skills gained from the execution of this career
development plan and research protocol will uniquely qualify me to be a leader in the fields of myocardial
mechanics, single ventricle physiology, and clinical drug and interventional trials in the pediatric population.

## Key facts

- **NIH application ID:** 9951086
- **Project number:** 5K23HL133447-04
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** Shahryar M. Chowdhury
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $200,772
- **Award type:** 5
- **Project period:** 2017-08-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9951086

## Citation

> US National Institutes of Health, RePORTER application 9951086, Heart Failure in Single Right Ventricle Physiology: Pathologic Mechanisms and Novel Assessment (5K23HL133447-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9951086. Licensed CC0.

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