# Precision Medicine Core

> **NIH NIH P30** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2020 · $176,868

## Abstract

PROJECT SUMMARY: PRECISION MEDICINE CORE
The goal of the Precision in Symptom Self-Management (PriSSM) Center is to advance the science of
symptom self-management for Latinos through a social ecological lens that takes into account variability in
individual, interpersonal, organizational, and environmental factors across the life course. Within the context of
the overall specific aims of the PriSSM Center, the aims of the Precision Medicine Core are to:
 1. Establish, refine, and maintain the Precision Medicine Core sociotechnical infrastructure for the
 collection and/or retrieval, storage, analysis, interpretation, and integration of multiple data sources to
 support the Center to (a) design and implement six symptom self-management pilot projects and (b) to
 create and maintain a common data element registry suitable for sharing with the National Institutes of
 Health and others,
 2. Expand and leverage existing institutional “omics” data resources including the Columbia GENomic
 Integration with Ehr (GENIE) virtual biobank,
 3. Provide expertise and guidance to Pilot Project investigators and other Center investigators on
 selection of data sources (genomic and other biomarkers, clinical, symptom self-reports, quantified-self,
 environmental) and analytic approaches (biostatistics, statistical genetics, data science) for symptom
 self-management, and
 4. Support the implementation of the data science components (e.g., network analysis, topic modeling) of
 the formative and summative evaluation plan.
To achieve these aims, the Precision Medicine Core integrates expertise and resources related to variety of
data sources (genomic and other biomarkers, clinical, symptom self-reports, quantified-self, environmental)
and analytic approaches (biostatistics, statistical genetics, data science). A federated information architecture
supports instantiation of the Social Ecological Model with multiple data sources and tools to enable precision in
characterization of genotype and phenotype, precision in identification of intervention targets, and precision in
intervention. The Precision Medicine Core is innovative in its focus on Latinos who vary significantly in genetic
ancestry as well as cultural background and in the use of the Columbia GENIE Virtual Biobank to locate
existing “omics” data resources for pilot projects. The proposed precision approaches will advance the science
of symptom self-management for Latinos in a manner consistent with the National Institutes of Health
Symptom Management Model.

## Key facts

- **NIH application ID:** 9951138
- **Project number:** 5P30NR016587-05
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** KATHLEEN T HICKEY
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $176,868
- **Award type:** 5
- **Project period:** — → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9951138

## Citation

> US National Institutes of Health, RePORTER application 9951138, Precision Medicine Core (5P30NR016587-05). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/9951138. Licensed CC0.

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