# Pesticide exposures, mental health and endocrine disruption among children growing up near pesticide spray sites.

> **NIH NIH K01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2020 · $158,230

## Abstract

Pesticides pose a public health risk to children living in agricultural communities. Children are particularly
vulnerable to the chronic effects of environmental contaminants such as insecticides, due to their size, physiology
and behavior. Worldwide, the two most widely used classes of insecticides are cholinesterase inhibitors
(organophosphates) and neonicotinoids. While some of the risks of organophosphates are known, to date, there
are no longitudinal studies of neurobehavioral or mental health outcomes in adolescents related to spatial
patterns of exposure to organophosphates and neonicotinoids. There is also no known research on the
associated neurobehavioral health alterations from neonicotinoid exposures in drinking or irrigation water. The
proposed study will leverage the parent, NIEHS-funded, longitudinal study of Secondary Pesticide Exposures
among Children and Adolescents (ESPINA), that examined 313 children (4-6 years old) in 2008, who live near
one of the highest concentrations of floriculture in the Americas, 535 adolescents in 2016, and is planning for a
subsequent examination in 2020. The proposed K01 will integrate biological monitoring, household survey, and
neurobehavioral examination data and utilize geospatial models and complex statistical techniques to: (1)
disentangle pathways of pesticide exposure, (2) study the geospatial determinants of neurobehavioral
performance (attention, memory, language, sensorimotor and visuospatial) and outcomes (anxiety and
depression) in children and adolescents from pesticide exposure, (3) test pesticide exposure in drinking water
and irrigation sources in proximity to floriculture. This is an application for a NIEHS Transition to Independent
Environmental Health Research (TIEHR) Career Award for Dr. Georgia Kayser, an early career Environmental
Health Assistant Professor in the Department of Family Medicine and Public Health in the School of Medicine at
the University of California, San Diego. Dr. Kayser aims to establish herself as an independent environmental
health investigator in the areas of pesticide exposure in children and adolescents and associated
neurobehavioral outcomes and expand her water and health research to include pesticides in drinking and
irrigation water. The award will provide Dr. Kayser with the support to achieve her career development goals: (1)
to develop advanced methodological skills in biostatistics and geospatial analysis; (2) to advance training on
child development and the interpretation and analysis of neurobehavioral assessment; (3) to acquire skills in
spatiotemporal analysis of pesticide exposure data and neurobehavioral outcomes, (4) identify points of
intervention and prevention to reduce pesticide exposure in children living in agricultural areas, (5) gain
independence. The research and training activities outlined here will generate new research to inform the design
of an intervention to be evaluated in an R01, and the application will be completed i...

## Key facts

- **NIH application ID:** 9953544
- **Project number:** 1K01ES031697-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Georgia L. Kayser
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $158,230
- **Award type:** 1
- **Project period:** 2020-09-21 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9953544

## Citation

> US National Institutes of Health, RePORTER application 9953544, Pesticide exposures, mental health and endocrine disruption among children growing up near pesticide spray sites. (1K01ES031697-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9953544. Licensed CC0.

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