# Cytokine regulation of T follicular helper (Tfh) cell biology

> **NIH NIH R01** · UNIVERSITY OF PENNSYLVANIA · 2020 · $402,500

## Abstract

Abstract
T follicular helper cells (Tfh) are central players in humoral immunity. However, the signals involved in inducing,
directing, and maintaining human Tfh differentiation are poorly understood. In this proposal we show
preliminary data identifying novel regulators of human Tfh differentiation. We proposal to validate these
findings, identify the molecular mechanisms of action of these regulators, and develop an integrated process
for inducing and regulating human Tfh cell differentiation.

## Key facts

- **NIH application ID:** 9954002
- **Project number:** 5R01AI123738-05
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Michela Locci
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $402,500
- **Award type:** 5
- **Project period:** 2017-07-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9954002

## Citation

> US National Institutes of Health, RePORTER application 9954002, Cytokine regulation of T follicular helper (Tfh) cell biology (5R01AI123738-05). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/9954002. Licensed CC0.

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