# Cell Biology, Pathology, and Imaging Core

> **NIH NIH P30** · UT SOUTHWESTERN MEDICAL CENTER · 2020 · $184,455

## Abstract

PROJECT SUMMARY/ABSTRACT
The Biomedical Research Core works in synergy to enhance bidirectional enhancement of research and flow of
data. The Cell Biology, Pathology, and Imaging Core (Core C) holds a central and critical place in phenotyping
in conjunction of the Physiology Core (Core). Core C will serve renal investigators in several areas: 1. Pathology.
2. Cell Biology. 3. Magnetic resonance imaging (MRI). For Pathology, we provide infrastructure, equipment,
service, and education on all standard techniques but we remain flexible for innovative and novel procedures as
the need arises. For Cell Biology, we offer to train investigators to perform confocal imaging in fixed and live cells
and allow them access to a state-of-the art microscopy suite. For whole animal Imaging, we offer standard MR-
based anatomic imaging, cardiac imaging for anatomy and cardiac function, and a wide variety of renal functional
MRI to measure a number of physiology and pathophysiologic parameters. We offer our assistance at three
levels depending on the nature of what is required to achieve the scientific endpoint.
For the highly standard established procedure, it is offered as a service where the investigators pay a small non-
profit cost recovery fee and the results are delivered in mutually agreed time frames. e.g. sectioning and H&E
stains. The Core will be cited but Core Directors will not be co-authors on any resultant manuscripts. For less
frequently used and more technical assays, the assistance will be provide as a collaboration. There will be clearly
defined deliverables with no charge but joint authorship is expected. e.g. functional MRI to measure renal blood
flow, oxygenation, and apparent diffusion coefficient of water (surrogate of fibrosis/cell infiltrate). Finally, studies
can be performed as an exploration where the investigators work with the Core Directors to discovery new
territories. e.g. spectral computed tomography.
The Cell Biology, Pathology, and Imaging Core remains one of cornerstones of phenotyping in the O'Brien
Center. In addition to transitional “workhorse” assays, we continuously explore new territories to advance the
technology. The Core contributes significantly to the mission of the O'Brien Center to conduct research in the
themes of kidney development and genetics, physiology and pathophysiology, and chronic kidney disease and
its complications, with the long term goal of improving diagnosis and treatment of kidney diseases.

## Key facts

- **NIH application ID:** 9954062
- **Project number:** 5P30DK079328-14
- **Recipient organization:** UT SOUTHWESTERN MEDICAL CENTER
- **Principal Investigator:** Orson W Moe
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $184,455
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9954062

## Citation

> US National Institutes of Health, RePORTER application 9954062, Cell Biology, Pathology, and Imaging Core (5P30DK079328-14). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9954062. Licensed CC0.

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