# Clinical and Translational Research Core

> **NIH NIH P30** · UT SOUTHWESTERN MEDICAL CENTER · 2020 · $253,195

## Abstract

PROJECT SUMMARY/ABSTRACT
This is the Clinical and Translational Core (Core D) as part of the competitive renewal of the UT Southwestern
O'Brien Kidney Research Center. The long-term objective of this Core is to facilitate translation of basic and
clinical discoveries into effective diagnostic and therapeutic strategies to improve the lives of patients with kidney
disease. We promote and directly facilitate bidirectional translation between basic and patient research. Since
the last competitive renewal we established the Core as an outstanding resource for Core Members to conduct
studies in patients with CKD including those with diabetes, hypertension and glomerular diseases. Investigators
have conducted innovative, high impact cutting-edge research in diverse ethnic and racial groups to improve
detection, diagnosis, prevention and treatment of those at very high risk for kidney disease progression and its
complications.
We now propose the following three specific aims: 1) develop a human kidney disease laboratory in the form of
registries and biorepository to study the pathogenesis, diagnosis and treatment of acute and chronic kidney
diseases in the areas of polycystic kidney disease, glomerulonephritis, peritoneal dialysis, and CKD- mineral
bone disorder, taking full advantage of the very large number of patients with these conditions in our practice; 2)
provide expertise, technical and logistical support in study design, protocol development and implementation for
conducting human clinical trials; and 3) provide educational enrichment programs for all investigators and their
trainees.
Core D functions in the spirit and mission of the O'Brien Center to advance our understanding of kidney
development and genetics, physiology and pathophysiology, and chronic kidney disease and its complication
with the eventual goal of improving diagnosis and treatment of kidney diseases.

## Key facts

- **NIH application ID:** 9954063
- **Project number:** 5P30DK079328-14
- **Recipient organization:** UT SOUTHWESTERN MEDICAL CENTER
- **Principal Investigator:** Orson W Moe
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $253,195
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9954063

## Citation

> US National Institutes of Health, RePORTER application 9954063, Clinical and Translational Research Core (5P30DK079328-14). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9954063. Licensed CC0.

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