# Project-001

> **NIH NIH U24** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $2,407,614

## Abstract

ABSTRACT
The goal of this U24 application is to establish a Coordinating Center (CC) for the next phase of the Adolescent
Medicine Trials Network for HIV/AIDS Interventions (ATN) sponsored by the NIH. The objective of ATN is to
increase awareness among at-risk youth of their HIV status and, for those with HIV, achieve linkage,
engagement and retention in the care continuum. Many challenges are faced by adolescents during their
transition to young adulthood, resulting from developmental changes, peer influences, identity, and self-esteem
formation. Risky behaviors among adolescents, which include engaging in unprotected sexual encounters or
sharing nonsterile injecting drug paraphernalia, increase their likelihood of acquiring HIV infection. In the 2013
US Youth Risk Behavior Surveillance Survey (YRBSS), 34% of US high school students reported sexual
intercourse during the prior 3 months, of which only 59% indicated condom use during last sexual intercourse.
The YRBSS also found that only 13% of students had ever been tested for HIV infection. Given the global
burden of new HIV infections among young people, greater involvement of adolescents in biomedical and
behavioral HIV research is essential. However, significant individual, operational, and community-level barriers
have been recognized to engaging adolescents in clinical prevention trials, which include insufficient
understanding of research, need for parental consent, lack of access, mistrust and stigma associated with
research participation. The new ATN is poised to address these issues. Central to its success will be an
innovative, forward-looking, and productive Coordinating Center that brings cohesion to the participating U19
investigators by sharing their visions and providing scientific leadership, organizational support and analytic
results for ATN projects. Key elements that will enhance collaboration and research progress include
experienced leadership, innovative design and analysis methodologies, comprehensive research operations
support, a state-of-the-art data management system, and superior administrative support. Our infrastructure
will provide both public and private websites which include ATN information pages for the public, participants,
and investigators, frequently asked questions, study materials, project calendar, a communications hub, and
other features. We will develop a secure, user-friendly advanced data management system that includes
web-based access for surveys, data entry, research management (including comprehensive reporting,
biosample tracking and performance-based reimbursement tools), integration with external applications, and
quality control. Our research operations and administration teams will provide a solid foundation to ATN by
facilitating communication including meeting arrangements and minutes, collaborative document preparation,
tracking of regulatory compliance, and support for abstract and publication preparation across the ATN.
Together, this...

## Key facts

- **NIH application ID:** 9954119
- **Project number:** 5U24HD089880-05
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Myra A. Carpenter
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $2,407,614
- **Award type:** 5
- **Project period:** — → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9954119

## Citation

> US National Institutes of Health, RePORTER application 9954119, Project-001 (5U24HD089880-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9954119. Licensed CC0.

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