# Core C - Statistics

> **NIH NIH U19** · UNIVERSITY OF WISCONSIN-MADISON · 2020 · $417,161

## Abstract

Abstract – Core C – Statistics Core
The overarching goal of this Core is to provide methodological and statistical support for research projects in
the U19, and facilitate the use of the rich MIDUS longitudinal data to the fullest extent possible by project
investigators. Core activities will encourage the development of innovative, integrative cross-project studies,
building on the extremely strong inter-disciplinary team of scientists and substantive aims shared by MIDUS
projects. The Core will also facilitate comparative analyses with other major NIA-funded surveys of aging, to
provide richer testing of hypotheses, replication of results and assessment of external validity, and, thereby,
develop a more integrative understanding of trajectories of health and well-being across the life course and
across cohorts. Core services are designed to complement and enhance the public use MIDUS data so that
the data provide the greatest value-added to the larger scientific community. A central component of the Core
is the development of ten semi-annual workshops, involving invited experts, project investigators, and public
users of the data, to examine integrative pathways using complex methods and shared measures, targeted
toward fully exploiting the multiwave, multi-cohort MIDUS data. Specifically, the core will: (1) promote maximal
use of complex multi-faceted MIDUS longitudinal data. We will take advantage of new scientific opportunities
afforded by the expanded panel data, while simultaneously attending to the temporal flow of data collected
across MIDUS projects, including comprehensive survey and cognitive assessments, and daily diary, in-depth
biomarker, neuroimaging, gene expression, and cytokine array data; (2) facilitate cross-project, interdisciplinary
investigations. Working with the project leaders, invited experts and public users, the Core will conduct
workshops to explore promising analytic strategies for quantifying profiles of reactivity and recovery, using data
from the biomarker (e.g., heart rate variability, salivary cortisol), neuroscience (e.g., neural activity assessed
with fMRI), and daily diary (e.g., daily stress) projects. and (3) integrate and coordinate analyses with other
major longitudinal studies. We will focus on studies capturing a broad range of birth cohorts, enabling
comparisons of health processes and outcomes across a range of sociohistorical contexts. We will exploit
MIDUS investigators' and External Advisor Board Members' deep knowledge of other studies with which they
are associated, including the English Longitudinal Study of Aging (ELSA), Health and Retirement Study (HRS),
Integrated Analysis of Longitudinal Studies of Aging (IALSA), National Social Life, Health and Aging Project
(NSHAP) Wisconsin Longitudinal Study (WLS), and other seminal data resources on aging. Taken together,
the Core will provide investigators with state-of-the-art tools and methods to fulfill the specific aims of the
research projects a...

## Key facts

- **NIH application ID:** 9955134
- **Project number:** 5U19AG051426-05
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** CAROL D. RYFF
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $417,161
- **Award type:** 5
- **Project period:** — → 2022-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9955134

## Citation

> US National Institutes of Health, RePORTER application 9955134, Core C - Statistics (5U19AG051426-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9955134. Licensed CC0.

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