# Virology BSL4 Core

> **NIH NIH P01** · WASHINGTON UNIVERSITY · 2020 · $160,000

## Abstract

The purpose of Core C is to provide support to the Projects and Core B for all high biocontainment work. The 
core brings unique expertise in molecular biology and cell biology of Ebola viruses. It also has high throughput 
assay capacity for measuring and quantitating virus infection efficiency that forms part of prioritization of host 
factors for follow up work in the other projects. The core will acquire, cultivate and characterize Ebola virus 
isolates that include those from the 2014 West Africa outbreak as well as make recombinant viruses containing 
amino acid changes that are produced from a reverse genetics system. The core will supply nucleic acids and 
cell lysates from viruses and infected cells. After host factors are identified and virus protein critical residues are 
known, from the Projects, each will be validated using cell lines infected with wild type and recombinant viruses. 
Animal work to evaluate pathogenesis will be performed using mouse models of disease. Each of these services 
supports key experiments performed in each Project ensuring that Core C will interact heavily with each part and 
be a key component of this Program Project.

## Key facts

- **NIH application ID:** 9955173
- **Project number:** 5P01AI120943-05
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** ROBERT A DAVEY
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $160,000
- **Award type:** 5
- **Project period:** 2016-07-07 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9955173

## Citation

> US National Institutes of Health, RePORTER application 9955173, Virology BSL4 Core (5P01AI120943-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9955173. Licensed CC0.

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