# Epigenetic Modifications in the Nonhuman Primate Model of Maternal Immune Activation

> **NIH NIH R21** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2020 · $195,908

## Abstract

Maternal infection during pregnancy has emerged from epidemiological research as a key factor in the risk for
neurodevelopmental disorders (NDD), including schizophrenia (SZ) and autism spectrum disorder (ASD).
Translational animal models demonstrate that maternal immune activation (MIA) negatively affects fetal
neurodevelopment and leads to the emergence of aberrant behavior later in life. Emerging evidence from rodent
MIA models suggests that prenatal immune challenge induces NDD-like phenotypes not only in exposed
individuals but also their descendants, suggesting that the risks of MIA may be exponentially greater than
previously understood. Although epigenomic mechanisms could explain both lifetime and transgenerational
effects associated with maternal infection, there are limitations in translating epigenetic findings from preclinical
rodent MIA models to humans. Our research program has extended the MIA model from rodents to nonhuman
primates, demonstrating that rhesus monkeys born the MIA-treated dams exhibit alterations in behavior, immune
function, and neural development. Here we propose to leverage the current UC Davis Conte Center funded
cohort of MIA exposed nonhuman primates to evaluate, for the first time, the effects of MIA on the primate’s
epigenome. This cohort also provides an unprecedented opportunity to explore the potential transgenerational
effects of MIA described in rodent models in a species more closely related to humans. We propose to examine
the immune cell and germ-line epigenome in MIA-exposed and CONTROL males as they mature from
adolescence into early adulthood. We will determine if these changes explain adverse neurobehavioral
development in the exposed generation and also confer risk for transgenerational inheritance of MIA effects.
Converging evidence from clinical and preclinical studies suggests that the epigenetic and transgenerational
mechanisms explored in the proposed studies may be relevant to a number of NDDs independent of current
diagnostic classifications. Thus the proposed studies may provide insight into the molecular mechanisms that
link prenatal immune challenge to long-lasting brain and behavior abnormalities that are relevant to a number of
human brain disorders associated with prenatal environmental insults.

## Key facts

- **NIH application ID:** 9955183
- **Project number:** 5R21AI148074-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Melissa Dawn Bauman
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $195,908
- **Award type:** 5
- **Project period:** 2019-06-14 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9955183

## Citation

> US National Institutes of Health, RePORTER application 9955183, Epigenetic Modifications in the Nonhuman Primate Model of Maternal Immune Activation (5R21AI148074-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9955183. Licensed CC0.

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