# Exploiting Masked Alcohols to Guide Atom-Transfer Reactions

> **NIH NIH R35** · DUKE UNIVERSITY · 2020 · $385,304

## Abstract

ABSTRACT
Fluorine incorporation into medicines, modern materials, and agricultural agents has improved their structural
stability and reinvented these domains. Yet the world has not fully realized fluorine's potential. One promising
approach to fluorine installation involves the direct transformation of a carbon–hydrogen bond (C–H bond) into
a carbon–fluorine bond in a process known as C–H functionalization. Yet C–H functionalization processes
have broader potential: they include reactions to replace C–H bonds with carbon–oxygen, carbon–sulfur,
carbon–chlorine or carbon–carbon bonds. In short, C–H functionalization reactions are powerful technologies
to streamline access to health-relevant small molecules. Over the last decade, some of the most important
advances in C–H functionalization originated from new platforms to control the site of this reaction. Still, the
utility of known C–H functionalization processes remains constrained by incomplete positional control in C–H
functionalization processes. In some cases, positional control can be achieved by using a directing group. The
proposed research includes new directing group strategies with the capacity to substantively extend the
synthetic utility C–H functionalization reactions, with tremendous potential benefit to human health.

## Key facts

- **NIH application ID:** 9955337
- **Project number:** 5R35GM128741-03
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Jennifer L Roizen
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $385,304
- **Award type:** 5
- **Project period:** 2018-07-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9955337

## Citation

> US National Institutes of Health, RePORTER application 9955337, Exploiting Masked Alcohols to Guide Atom-Transfer Reactions (5R35GM128741-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9955337. Licensed CC0.

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