# 2/7 Psychiatric Genomics Consortium: Finding Actionable Variation

> **NIH NIH U01** · MASSACHUSETTS GENERAL HOSPITAL · 2020 · $90,010

## Abstract

ABSTRACT
In the past years, the Psychiatric Genomics Consortium has led many extremely successful large-scale genetics
studies -- identifying hundreds of loci underlying psychiatric disorders and providing initial insights into the
disease pathogenesis. However, most of these studies focused on European ancestry populations. Without the
global human genetic diversity, this bias has cost us important scientific knowledge and impeded the application
of existing genetic findings to most of the world’s population. To address this important gap in scientific
knowledge and to advance global mental health equity, we propose a supplement to the parent award to support
an effort to compile a sample of over 30,000 schizophrenia patients and similar number of matched controls of
East Asian ancestry. We will leverage this sample to identify novel genetic loci associated with schizophrenia in
the East Asian ancestry and across the world, to evaluate the transferability of the polygenic risk score, and to
elucidate the contribution of the major histocompatibility complex locus to schizophrenia. Findings from this
supplement will provide additional insights into the schizophrenia genetic architecture, especially in its genetic
epidemiology across the word populations. This supplement will be a critical enhancement to the existing PGC
efforts and the parent award.

## Key facts

- **NIH application ID:** 9955494
- **Project number:** 3U01MH109539-04S1
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Mark Joseph Daly
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $90,010
- **Award type:** 3
- **Project period:** 2019-07-01 → 2021-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9955494

## Citation

> US National Institutes of Health, RePORTER application 9955494, 2/7 Psychiatric Genomics Consortium: Finding Actionable Variation (3U01MH109539-04S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9955494. Licensed CC0.

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