# Randomized controlled trial of an implementation science tool to increase cervical cancer screening in Mombasa, Kenya

> **NIH NIH K08** · UNIVERSITY OF WASHINGTON · 2020 · $188,892

## Abstract

ABSTRACT
Summary of Proposal: This proposal supports a 4-year research and training program to allow Dr. Eastment to
make substantial progress toward a career as an independent investigator and leader in the field of women’s
health and cervical cancer screening implementation. She aims to quantify the cervical cancer screening care
cascade and understand the correlates of appropriate screening. She will then conduct a cluster randomized
trial to test an implementation science tool, the Systems Analysis and Improvement Approach (SAIA), to improve
cervical cancer screening for both HIV-positive and HIV-negative women in Mombasa, Kenya. A budget impact
analysis of SAIA will be performed for Mombasa County Department of Health (DOH). Dr. Eastment’s expertise
in coordinating studies in Kenya utilizing the same implementation science tool provides a strong foundation for
this proposed plan. Her training program will include further instruction in study design, economic evaluations,
analysis of correlated data, and implementation science from leaders in these fields, leveraging on the
outstanding research and training environments at the University of Washington (UW), and the strength of long-
term collaborations with Mombasa County. Her collection of mentors from the UW Departments of Medicine,
Biostatistics, Epidemiology, and Global health, along with her collaborators from Mombasa County, are eager to
mentor and support Dr. Eastment’s project and career development. Research Plan: Cervical cancer is the most
common cancer in women in sub-Saharan Africa, and the majority of cervical cancer mortality occur in low and
middle income countries (LMICs). Many of the disparities between high and LMICs are attributed to differences
in screening. Kenyan guidelines recommend screening with visual inspection methods followed by treatment of
pre-cancerous lesions with cryotherapy and loop electrosurgical excision procedure (LEEP). Implementation of
these are poor with only 14% of Kenyan women ever having been screened for cervical cancer as of 2014. To
address this implementation gap, this application proposes three aims. In Aim 1, we will describe the cervical
cancer screening care cascade, from identification of female clients age 21-65 years old, through referral for
follow-up of clients with positive or suspicious screens, in family planning (FP) clinics in Mombasa County.
Following characterization of this cascade, we will conduct an analysis of correlates of failure to screen for
cervical cancer in FP clients seen over a one-year period in Mombasa County. Aim 2 will test whether SAIA
increases cervical cancer screening compared to usual procedures in a cluster randomized trial in 20 FP clinics
in Mombasa County. Finally, in Aim 3, we will determine the cost and budget impact of using SAIA to increase
cervical cancer screening in FP clinics in Mombasa County. The results of this study have the potential to improve
cervical cancer screening, and inform policy...

## Key facts

- **NIH application ID:** 9957033
- **Project number:** 5K08CA228761-03
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** McKenna Claire Eastment
- **Activity code:** K08 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $188,892
- **Award type:** 5
- **Project period:** 2018-07-06 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9957033

## Citation

> US National Institutes of Health, RePORTER application 9957033, Randomized controlled trial of an implementation science tool to increase cervical cancer screening in Mombasa, Kenya (5K08CA228761-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9957033. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*