# Determining the induction of hemagglutinin stalk and neuraminidase antibody responses after LAIV vaccination in children

> **NIH NIH R21** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $254,250

## Abstract

Summary
Influenza virus vaccines are widely used. It is known that there are differences in the breadth and duration of
protection between inactivated (IIV) and live attenuated influenza virus (LAIV) vaccines with the latter inducing
broader and longer lasting protection. However, it is unclear which factors are causing these differences. Here
we aim to characterize the LAIV induced antibody response in peripheral blood and mucosal fluids to
conserved epitopes on the viral hemagglutinin and neuraminidase. We hypothesize that induction of antibodies
to conserved sites contributes to the better protection observed with LAIV. To investigate this, we will
interrogate a unique set of samples from clinical trials performed with LAIV over two seasons in The Gambia.
Data from this study will help us to better understand the mechanism of broad protection of LAIV and it will
allow to gauge the potential of using LAIV as prime for subsequent boosts with hemagglutinin-stalk and/or
neuraminidase based universal influenza virus vaccines.

## Key facts

- **NIH application ID:** 9958668
- **Project number:** 1R21AI151917-01
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Florian Krammer
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $254,250
- **Award type:** 1
- **Project period:** 2020-03-05 → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9958668

## Citation

> US National Institutes of Health, RePORTER application 9958668, Determining the induction of hemagglutinin stalk and neuraminidase antibody responses after LAIV vaccination in children (1R21AI151917-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9958668. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*