# Developmental neurobiological and contextual influences on alcohol use disorder

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $560,184

## Abstract

Abstract
Alcohol use and alcohol use disorder (AUD) exhibits strong age-related patterns, specifically, initiation and
escalation in adolescence, peak use and prevalence in emerging adulthood, followed by a substantial decline
in young adulthood. Underlying these general patterns, however, there is substantial variation in terms of the
onset, persistence, and severity of AUD. These patterns are influenced by individual differences in brain
structure and function both in terms of initial risk and the rate of neurological maturation, the latter of which is
affected by alcohol and drug use. In addition to exposure to substances, however, a person's broader
environmental context includes a number of influences that impact neural development and increase or
decrease risk for AUD. Delineating the complex interplay among the different neural and environmental
influences that contribute to the emergence and persistence versus desistence of AUD requires tracking the
co-development between substance use, neural processes, and contextual variables prior to the initiation of
use and continuing past young adulthood after which AUD rates have peaked and begun to decline.
We propose to do so by continuing to follow two cohorts of offspring from the Michigan Longitudinal Study
(MLS) who have been participating in longitudinal neuroimaging. The MLS is a high-risk family study with a
high prevalence of substance use disorders in the parental generation (>60%). The offspring generation has
been followed beginning at ages 3-5 years old with intensive assessments of individual-level and contextual
risk factors at 3-year intervals and annual assessments of substance use and risk factors beginning at age 11.
Longitudinal neuroimaging of MLS participants (N=340) at one- to two-year intervals began in either childhood
(n=130; baseline Mage=10 years, current Mage=16 years) or young adulthood (n=210; baseline Mage=20 years,
current Mage = 26 years) including structure, resting state, and task-related activation focused on cognitive
control and reward processes. We propose additional longitudinal scans, up to age 21 in the child cohort, and
up to age 30 in the young adult cohort. This will provide a dense number of assessments of brain structure,
function and connectivity across the developmental period of childhood to young adulthood (ages 7-30). Our
approach will emphasize sophisticated analytic methods to extract maximal information from the neuroimaging
data (e.g., focus on circuit-based patterns using independent components analysis) to chart normative brain
development, identify neurobiological risk for AUD, and determine the impact of alcohol use on brain
development. We will also use longitudinal models to incorporate the role of environmental influences on both
AUD and brain development with an emphasis on life transitions associated with increases (sexual initiation,
leaving home) or decreases (marriage, parenthood) in alcohol use. The proposed study will be uniqu...

## Key facts

- **NIH application ID:** 9960385
- **Project number:** 5R01AA025790-03
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** BRIAN M HICKS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $560,184
- **Award type:** 5
- **Project period:** 2018-09-10 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9960385

## Citation

> US National Institutes of Health, RePORTER application 9960385, Developmental neurobiological and contextual influences on alcohol use disorder (5R01AA025790-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9960385. Licensed CC0.

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