# Asymmetric Chemical Synthesis Methods via Cooperative Catalysis

> **NIH NIH R01** · TRUSTEES OF INDIANA UNIVERSITY · 2020 · $294,364

## Abstract

Abstract
The straightforward laboratory preparation of structural motifs commonly found in therapeutic agents is a major
driving force in catalysis-based reaction design. In our laboratory we have adopted cooperative catalysis, an
approach that emulates mechanisms encountered in enzymatic activity. In such a regime, merges of two (or
more) simultaneous and complementary catalysis events are merged to forge a single chemical bond, via
hitherto inaccessible chemical reactivity. Despite the infancy of this area, it promises much for the design of
new, efficient and operationally trivial catalytic asymmetric reactions, and expedite the design, development
and manufacture of medicines to manage and treat diseases.
Based on exciting preliminary data we have obtained in the arena of cooperative catalysis, the program
detailed in this proposal will provide the scientific community with straightforward, reliable and flexible methods
for chemical synthesis This work will significantly impact human health and medicine by establishing routine
synthetic protocols for the preparation of valuable molecular scaffolds, which will contribute to the design and
development of new clinical agents.

## Key facts

- **NIH application ID:** 9960523
- **Project number:** 5R01GM121573-05
- **Recipient organization:** TRUSTEES OF INDIANA UNIVERSITY
- **Principal Investigator:** Thomas Neil Snaddon
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $294,364
- **Award type:** 5
- **Project period:** 2016-09-20 → 2021-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9960523

## Citation

> US National Institutes of Health, RePORTER application 9960523, Asymmetric Chemical Synthesis Methods via Cooperative Catalysis (5R01GM121573-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9960523. Licensed CC0.

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