# Project 01: Understanding Racial Disparity in Endometrial Cancer through Tumor Genomics

> **NIH NIH P20** · NORTHWESTERN UNIVERSITY · 2020 · $216,962

## Abstract

Abstract
The incidence of endometrial cancer is on the rise each year reaching over 60,000 new cases for 2017. As
risk factors remain prevalent in both adults and children, more and more women including those of younger
age will develop endometrial cancer. Studies demonstrate an obvious race disparity in endometrial cancer
where black women present with more aggressive disease and a higher death rate compared to white women.
While reasons for this are multifactorial, the biological etiology remains to be studied. In this project, we will
collect endometrial tumors and its associated clinical information from black and white women. Exome
sequencing will be performed and along with clinical data, bioinformatics analysis will be done to determine the
racial differences in tumor genomics. In addition, it is unknown whether the tumors in black women respond to
progestin similarly to white women. This is an important piece of the puzzle as young black women have
increased severity of disease than white women. Endometrial tumor spheroids will be used to determine
progestin response of the tumors ex vivo and with information from exome sequencing, a predictive signature
will be generated, which may or may not be different in black women. Finally, an alternative to progestin
therapy will be tested ex vivo as an improvement to progestin therapy. This research will increase our
understanding of racial differences in endometrial cancer and their response to existing progestin
treatments. The impact of our studies will be significant, as we obtain evidence and design tools to improve
progestin therapy in endometrial cancer in both black and white women in a personalized manner.
!

## Key facts

- **NIH application ID:** 9961261
- **Project number:** 1P20CA233304-01A1
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Ji-Yong Julie Kim
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $216,962
- **Award type:** 1
- **Project period:** 2020-09-17 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9961261

## Citation

> US National Institutes of Health, RePORTER application 9961261, Project 01: Understanding Racial Disparity in Endometrial Cancer through Tumor Genomics (1P20CA233304-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9961261. Licensed CC0.

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