# RNA Sequencing Via Single Reverse Transcript Assessments

> **NIH NIH R43** · ELECTRONIC BIOSCIENCES, INC. · 2020 · $279,999

## Abstract

Project Summary
While very substantial progress has been made over the last 10 or so years with regards to next generation
sequencing (NGS) and third generation sequencing (TGS) of DNA, the development of novel and enabling tool
sets for RNA sequencing has lagged significantly. During this project, we aim to make significant progress with
regards to that gap by developing and validating an entirely new solid-state sequencing platform, developed
specifically and ideally for direct RNA sequencing, including its structural complexities and nucleotide
modifications, all with high accuracy. While there are over 100 known RNA nucleotide modifications, due to the
lack of analytical characterization methods available, the exact roles of these modifications remain to be
determined. The technology that will be developed during the project will be capable of elucidating the roles of
these modifications, and revolutionizing our understanding and use of the transcriptome/epitranscriptome.

## Key facts

- **NIH application ID:** 9961426
- **Project number:** 1R43HG011070-01
- **Recipient organization:** ELECTRONIC BIOSCIENCES, INC.
- **Principal Investigator:** Sean German
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $279,999
- **Award type:** 1
- **Project period:** 2020-05-01 → 2021-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9961426

## Citation

> US National Institutes of Health, RePORTER application 9961426, RNA Sequencing Via Single Reverse Transcript Assessments (1R43HG011070-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/9961426. Licensed CC0.

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