# Animal Core B

> **NIH NIH P01** · UNIVERSITY OF ARIZONA · 2020 · $377,196

## Abstract

PROJECT SUMMARY-ANIMAL CORE B
The mission of our Perimenopause in Brain Aging and Alzheimer's Disease Program Project (P3) is to
discover biological transformations in brain that occur during the perimenopausal transition that lead to
endophenotypes predictive of risk for Alzheimer's disease (AD). Our goals are to identify the mechanisms
by which these transformations occur and to translate these discoveries into strategies to prevent
conversion to an at-Alzheimer's-risk phenotype. The proposed program of research builds on our discovery
of the perimenopausal bioenergetic transition in brain and its predictive association with cognitive decline in
postmenopausal women to investigate the impact of the APOE4 allele on this uniquely female aging
experience. Outcomes of our mechanistic to clinical to global population program of research could provide
insights into the increased burden of the ApoE4 gene and risk of AD in ApoE4 positive women.
The mission of Animal Core (Core B) is to ensure the success of the Perimenopause Program Project
through provision of animals as needed to Projects 1–2. To achieve its mission, the Animal Core will extend
previously developed rodent models of perimenopause and menopause to humanized ApoE4 and ApoE3
rodent mice and rat models; maintain and track animals from acquisition or birth, determination of cycling
status and perimenopausal transition, randomized study enrollment, experimental manipulation, to tissue
collection across the entire Perimenopause Program Project; and obtain blinded tissue samples for
analyses by Analytic Core and/or Projects.

## Key facts

- **NIH application ID:** 9961467
- **Project number:** 5P01AG026572-15
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** Enrique Cadenas
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $377,196
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9961467

## Citation

> US National Institutes of Health, RePORTER application 9961467, Animal Core B (5P01AG026572-15). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9961467. Licensed CC0.

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