# Analytic Core C

> **NIH NIH P01** · UNIVERSITY OF ARIZONA · 2020 · $377,304

## Abstract

PROJECT SUMMARY-ANALYTIC CORE C
The mission of our Perimenopause in Brain Aging and Alzheimer's Disease Program Project (P3) is to
discover biological transformations in brain that occur during the perimenopausal transition that lead to
endophenotypes predictive of risk for Alzheimer's disease (AD). Our goals are to identify the mechanisms
by which these transformations occur and to translate these discoveries into strategies to prevent
conversion to an at-Alzheimer's-risk phenotype. To achieve our Perimenopausal Program Project mission,
we have developed a set of integrated program-wide specific aims that span mechanistic discovery to
clinical neuroimaging in ApoE genotyped perimenopausal and postmenopausal women to a global
population through the ENIGMA network of neuroimages, clinical data and ApoE genetics. The mission of
Analytic Core is to provide standardized steroid hormone regimens, sample archiving, processing and
distribution, as well as analytic support across the Perimenopausal Program Project. The mission of
Analytic Core is to provide standardized steroid hormone regimens, sample archiving, processing and
distribution, as well as analytic support across the Program Project. To achieve this mission, the Analytic
Core will provide two levels of support. The first level of support entails standardized steroid hormone
regimens and sample management. The second level of support entails sample analysis and data
interpretation on four major studies: LC-MS/MS steroid analysis, ApoE genotyping, custom array gene
expression analysis, and bioinformatic gene functional analysis. Analytic Core was an instrumental and
essential resource for the previous Progesterone Program Project and the currently ongoing
Perimenopause Program Project. Through the infrastructure and analytic methods it has developed,
Analytic Core will continue to play a crucial role in achieving the renewed Perimenopausal Program
Project's mission and aims.

## Key facts

- **NIH application ID:** 9961468
- **Project number:** 5P01AG026572-15
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** Enrique Cadenas
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $377,304
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9961468

## Citation

> US National Institutes of Health, RePORTER application 9961468, Analytic Core C (5P01AG026572-15). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9961468. Licensed CC0.

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