# Cerebral Substrate Support After Traumatic Brain Injury

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2020 · $341,250

## Abstract

Project Summary/Abstract
Basic science and clinical research has shown that traumatic brain injury (TBI) results in immediate and
transient increases in glucose uptake (CMRglc) to re-establish ionic equilibrium and neurochemical
imbalances. This is rapidly followed by a prolonged period of glucose metabolic depression, a hallmark
of TBI and a critical component of the cerebral metabolic crisis. During this depression the brain is
vulnerable and there are many problems with glucose metabolism. We have shown that early
administration of alternative substrates after injury reduces cell loss, improves cellular energy and early
beahvioral outcomes. This grant will directly compare the capacity of alternative substrates to
decrease metabolic crisis, improve mitochondrial energy, decrease free radical damage and improve
long-term function in both male and female subjects. Findings from these studies will establish which
brain fuels are optimal for recovery in both genders after TBI.

## Key facts

- **NIH application ID:** 9961674
- **Project number:** 5R01NS104311-03
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Mayumi Lynn Prins
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $341,250
- **Award type:** 5
- **Project period:** 2018-09-30 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9961674

## Citation

> US National Institutes of Health, RePORTER application 9961674, Cerebral Substrate Support After Traumatic Brain Injury (5R01NS104311-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9961674. Licensed CC0.

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