# Neuroimaging Core I

> **NIH NIH P30** · UNIVERSITY OF PENNSYLVANIA · 2020 · $906,909

## Abstract

UNIVERSITY OF PENNSYLVANIA ALZHEIMER’S DISEASE CORE CENTER ABSTRACT: REVISION TO
CREATE A NEW NEUROIMAGING CORE (CORE I) ADCC Director and Principal Investigator: John Q.
Trojanowski, MD, PhD; Neuroimaging Core Leaders: John A Detre, MD and Paul A. Yushkevich, PhD
This is an application for a revision of the University of Pennsylvania (Penn) Alzheimer Disease Core Center
(ADCC) to establish an independent Neuroimaging Core (Core I). Currently, no dedicated neuroimaging
infrastructure exists in Penn’s ADCC. Neuroimaging has emerged as a key approach for detecting and
quantifying molecular neuropathology and resultant neurodegeneration in vivo, and neuroimaging biomarkers
are contributing an increasing role to the diagnosis and prognosis of Alzheimer’s disease (AD) by staging patients
along the AD continuum (i.e. preclinical through dementia). Advances in structural, functional, and molecular
neuroimaging methodologies continue to expand the sensitivity, specificity, and appeal of these approaches,
due in part to the non-invasiveness of image acquisition as compared to other potential biomarkers. The
proposed Neuroimaging Core will create new infrastructure within the Penn ADCC to support state-of-the-art
neuroimaging acquisition and informatics and provide ADCC investigators with access to resources and
expertise needed to fully integrate neuroimaging metrics into clinical evaluation, clinical-pathological correlations,
and genomic analyses. Aim 1 of the proposed Neuroimaging Core I will leverage leading neuroimaging expertise
to support the development, acquisition, and analysis of state-of-the-art structural, functional, and molecular
neuroimaging, including use of ultra-high-field imaging (7 Tesla) and novel PET ligands, and their applications
as noninvasive biomarkers of AD neuropathology in the ADCC Clinical Core B cohort. As there is limited work
linking quantitative measures of various proteinopathies and their interactions with three-dimensional structural
brain changes across the cortical mantle, Aim 2 establishes linkage between in vivo neuroimaging and
quantitative postmortem digital pathology via high-resolution MRI of intact autopsy brain specimens and image
guided tissue sampling for digital pathology, in collaboration with Neuropathology Core D. Aim 3 will establish a
new data infrastructure that will link multiscale in vivo, ex vivo, and digital microscopy imaging data with the
extensive clinical, behavioral, and biofluid database maintained by Bioinformatics and Biostatistics Core C and
enable flexible inquiry and discovery across clinical, pathological, genetic, and imaging modalities as well as
facilitate data sharing. Training in Neuroimaging will also occur in collaboration with Education Core F.

## Key facts

- **NIH application ID:** 9962210
- **Project number:** 5P30AG010124-30
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** JOHN A DETRE
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $906,909
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9962210

## Citation

> US National Institutes of Health, RePORTER application 9962210, Neuroimaging Core I (5P30AG010124-30). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9962210. Licensed CC0.

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