# Biostatistics and Bioinformatics Shared Resource Facility

> **NIH NIH P30** · UNIVERSITY OF KENTUCKY · 2020 · $233,455

## Abstract

PROJECT SUMMARY/ABSTRACT
 The Biostatistics and Bioinformatics Shared Resource Facility (BB SRF) is an essential cancer center-
managed resource and has played a critical role as members in team science by providing statistical and
bioinformatics expertise to enable and enhance the Markey Cancer Center’s (MCC) basic, clinical and
population research. BB SRF services are categorized broadly into: 1) study planning, power and sample size
calculations for grant applications; 2) design and implementation support for clinical trials; 3) statistical
analyses, including interim and final analysis for the entire spectrum of cancer research studies; 4)
bioinformatics methods for design and analysis of high-throughput ’omics data; 5) statistical programming for
data quality control and data processing; and 6) mentoring, education and general consultation to MCC
investigators. BB SRF services are coordinated with other MCC SRFs with hand-offs and integrated workflows
to ensure comprehensive, seamless and non-overlapping support. During the current funding cycle, the BB
SRF has made significant scientific impact by employing technical methodologies directly supporting MCC
Research Program themes. These technical methodologies include development and implementation of state-
of-the-art data processing and data analysis pipelines and software for several genomic platforms with specific
applications to Kentucky’s Appalachian population; novel differential analysis and classification methodologies
for metabolomics and exosome data for lung, breast and pancreas cancers; adaptive and model-based dose
finding designs and state-of-the art designs for early phase trials with biomarker and genomic evaluations of
targeted therapies; statistical methodologies for population-based cancer prevention studies including
nonparametric estimation and hypothesis testing of risk factor distributions, relative survival estimation and
statistical methods for cancer registry and large claims databases to support research in MCC’s research in
health disparities. In addition to support as co-investigators in 52 newly funded grants and over 40 investigator-
initiated trials, BB SRF faculty engaged in novel methodological work to enhance the science of MCC
Research Programs. During the current CCSG funding cycle, the BB SRF supported 128 MCC members (81
peer-reviewed funded) from all 4 MCC Research Programs, representing 74% coverage from the total MCC
membership.
 The BB SRF has significantly increased usage and value added metrics, expanded its services and has
grown in personnel from 8 faculty and staff to a current total of 14 to address the growth and emerging
research directions of the MCC. The highly experienced personnel and diverse skill set of the BB SRF adds
significant value to the execution of scientifically rigorous research at the MCC and demonstrates that the BB
SRF is well positioned to support the MCC as a Comprehensive Cancer Center for the Commonwealth of
Kentucky i...

## Key facts

- **NIH application ID:** 9962312
- **Project number:** 5P30CA177558-08
- **Recipient organization:** UNIVERSITY OF KENTUCKY
- **Principal Investigator:** Heidi L Weiss
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $233,455
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9962312

## Citation

> US National Institutes of Health, RePORTER application 9962312, Biostatistics and Bioinformatics Shared Resource Facility (5P30CA177558-08). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9962312. Licensed CC0.

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