# The role of inflammation in the progression of polycystic kidney disease

> **NIH NIH R01** · UNIVERSITY OF COLORADO DENVER · 2020 · $189,000

## Abstract

ABSTRACT
Autosomal dominant polycystic kidney disease (ADPKD) is the most common life threatening hereditary
disease in the United States, affecting an estimated 1 in 500 people. Approximately 50% of ADPKD patients
develop end-stage renal disease (ESRD) by 50 years of age, and ADPKD accounts for 5-10% of ESRD in the
United States and Europe.
Affected patients may be asymptomatic for many years despite radiographic evidence of marked architectural
distortion of renal parenchyma. Therefore, there is an immediate need for specific and sensitive biomarkers
that are early predictors of disease severity and progression.
We hypothesize that changes in the production of bioactive lipids will correlate with severity and
progression of ADPKD. Validated targeted mass spectrometry-based approaches will be used to identify and
validate biomarkers in HALT PKD trial patient samples.
In our previous studies, we have identified several bioactive lipid markers that associated with the progression
of ADPKD (assessed as the increase in total kidney volume over a period of 3 years) in children and young
adults with normal renal function. In this study we will validate these lipid peroxidation products as predictive
markers of disease progression. In the last step, we will identify mechanisms that contribute to the changes in
biomarkers through a redox proteomics tool. Pathway and network analysis will provide insights into novel
pathophysiological pathways of disease progression. Ultimately such knowledge can be applied towards the
stratification of patients based upon their rate of disease progression and towards the development of novel
interventions for treatment of ADPKD.

## Key facts

- **NIH application ID:** 9962385
- **Project number:** 5R01DK114424-03
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Berenice Yolande Gitomer
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $189,000
- **Award type:** 5
- **Project period:** 2018-09-15 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9962385

## Citation

> US National Institutes of Health, RePORTER application 9962385, The role of inflammation in the progression of polycystic kidney disease (5R01DK114424-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9962385. Licensed CC0.

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