# Human Translational Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2020 · $260,066

## Abstract

Summary
 The objective of the Human Translational Core is to facilitate bench-to-bedside translational studies by
providing members of the San Diego Digestive Diseases Research Center ready access to human
biospecimens of well-characterized cohorts of patients with digestive diseases. Moreover, The Core will provide
clinical expertise for examining paradigms that emerge from basic studies conducted in animals and in vitro and
relating them to clinical phenotypes seen in patients with digestive diseases. The Core will be led by highly
accomplished clinical and translational researchers from the University of California, San Diego (UCSD) Division
of Gastroenterology, with Dr. Rohit Loomba as Director, Dr. William Sandborn as Co-Director, and Dr. Sheila
Crowe as Co-Investigator. Drs. Loomba and Sandborn have already established modest biorepositories in the
Nonalcoholic Fatty Liver Disease (NAFLD) Center and Inflammatory Bowel Disease (IBD) Center, respectively.
The proposed Core will build on these achievements and markedly expand and streamline the repository of
biospecimens from well-characterized digestive disease patients as well as appropriate controls. Established
strengths of this Core include the outstanding track record of the Core leadership in translational research related
to inflammation in gastrointestinal and liver diseases; their experience in detailed phenotyping of patients with
digestive diseases; access to existing and well-characterized cohorts of patients with specific digestive diseases;
access to a biorepository of existing human biospecimens; synergistic interactions and the availability of state-
of-the-art data management resources; and strong pathological and biostatistical expertise. This Core will
interact with and complement the Preclinical Models and Microbiomics and Functional Genomics Cores by
facilitating research to relate biomarkers and preclinical data from animal models to specific outcomes in patients
with digestive diseases. The Human Translational Core has the following Aims: 1. To collect, process and
annotate human tissue samples, including liver biopsies, endoscopic gastrointestinal tissues, whole blood,
plasma, serum, peripheral blood mononuclear cell (PBMC), and stool; 2. To provide human biospecimens
coupled with patient metadata to Center investigators; 3. To offer clinical, biostatistical and pathological
consultation services, as well as training opportunities. Thus, this Core will benefit the Center members by
providing reliable, cost-effective services for enhancing the scope and innovation of their research and its
relevance to human diseases of the digestive tract.

## Key facts

- **NIH application ID:** 9962392
- **Project number:** 5P30DK120515-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** ROHIT LOOMBA
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $260,066
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9962392

## Citation

> US National Institutes of Health, RePORTER application 9962392, Human Translational Core (5P30DK120515-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9962392. Licensed CC0.

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