# Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN)

> **NIH NIH U24** · UNIVERSITY OF CINCINNATI · 2020 · $147,339

## Abstract

The University of Cincinnati (UC) Hub and Spoke System combines the strengths of three regional academic
health centers (AHC) and several community hospitals to provide a robust and readily accessible infrastructure
for rapid implementation and high quality performance of clinical trials in a breadth of emergency indications.
Our institution and our partners have a strong history of outstanding acute clinical trial performance spanning
the prehospital, emergency department (ED), hospital floor and intensive care unit (ICU) environments. Our
Hub and Spoke System has a proven history of effective clinical trial enrollments combined with efficient
protocol adherent practices. UC will serve as the administrative Hub for our network. Our AHC spokes at
University of Kentucky and University of Louisville will expand our catchment of acutely ill and injured patients,
and the SIREN Network will benefit from their existing research infrastructures. The unique patient populations
of the AHC spokes will be complemented by our community hospital spokes; our partnership with these
community hospitals has an established track record of success in Cincinnati. Furthermore, the SIREN
objectives uniquely align with UC’s institutional and Clinical and Translational Science Award (CTSA)
objectives, especially our Acute Care Research Council; this Council aims to build a coordinated acute care
research program that covers the entire region. Expertise of our leadership team include prehospital care,
emergency cardiac care, emergency neurological care, and trauma/critical care. Our overarching goal is to
bring more than just participants to the SIREN Network; we will meaningfully contribute to the growth and
success of SIREN through communication and collaboration with other systems to maximize the effectiveness
of the entire network.

## Key facts

- **NIH application ID:** 9962512
- **Project number:** 5U24NS100688-04
- **Recipient organization:** UNIVERSITY OF CINCINNATI
- **Principal Investigator:** Opeolu M Adeoye
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $147,339
- **Award type:** 5
- **Project period:** 2017-07-15 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9962512

## Citation

> US National Institutes of Health, RePORTER application 9962512, Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) (5U24NS100688-04). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9962512. Licensed CC0.

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