# Use and outcomes of anticoagulants for the treatment and prevention of thrombosis among hospitalized patients

> **NIH NIH K24** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $121,834

## Abstract

ABSTRACT
More than 2 – 3 million people are prescribed anticoagulants every year in the United States for the treatment
and prevention of thromboembolic conditions. Used for indications ranging from stroke-prevention in atrial
fibrillation to the acute treatment of venous thromboembolism, anticoagulants can significantly reduce the
morbidity and mortality related to thromboembolism. However, anticoagulants are also associated with
significant risks of bleeding, as well as costs and burden to patients. The overall objective of this proposal is to
gain greater insight into the optimal use of anticoagulants in different clinical situations, with the ultimate goal
being to maximize their benefits and minimize their risks. The other over-arching goal of the proposal is to
allow Dr. Fang to build upon a successful history of mentoring trainees and faculty in order to develop a
research and mentoring program geared towards training junior investigators preparing for careers in patient-
oriented cardiovascular outcomes research.
The research aims of this proposal will address the contemporary use of pharmacologic prevention strategies
to prevent venous thromboembolism after joint replacement surgery, describe trends in the periprocedural
management and outcomes of patients who need to interrupt chronic anticoagulant therapy in order to undergo
elective surgery, and examine the association between anticoagulant treatment satisfaction, health-related
quality-of-life, and medication adherence in people taking oral anticoagulants. These aims will help inform the
appropriate use of anticoagulants in clinical practice.
As a hospital-based clinician investigator, Dr. Fang serves as the Research Director for the University of
California, San Francisco (UCSF) Division of Hospital Medicine. Her research program is based in the
outstanding clinical, training, and research environment of UCSF. The aims of this proposal will support her
efforts in developing cardiovascular outcomes researchers, as well as strengthen the capacity that her
research platform has to support mentee research.

## Key facts

- **NIH application ID:** 9963353
- **Project number:** 5K24HL141354-03
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** MARGARET C. FANG
- **Activity code:** K24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $121,834
- **Award type:** 5
- **Project period:** 2018-07-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9963353

## Citation

> US National Institutes of Health, RePORTER application 9963353, Use and outcomes of anticoagulants for the treatment and prevention of thrombosis among hospitalized patients (5K24HL141354-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9963353. Licensed CC0.

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