# Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) - Pittsburgh

> **NIH NIH U24** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $148,796

## Abstract

The Pennsylvania Consortium for Emergency Research will leverage our experience and infrastructure to
participate in the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). The University
of Pittsburgh will act as a Hub with strong academic and clinical partners at the Thomas Jefferson
University, Allegheny Health Network, and the Pennsylvania State University. Each partner is affiliated with
a health system that can provide additional clinical sites within the region for future growth. This
geographically tight collaboration, with access to emergency patients and emergency medical services in
rural, suburban and urban parts of Pennsylvania, will participate in network emergency care trials with the
following Aims: (1) Provide administrative structure to rapidly implement and enroll in clinical trials of
emergency treatments. (2) Minimize time, cost and regulatory barriers to multicenter clinical trials in
emergency settings. (3) Explore innovative strategies to increase identification, recruitment, and consent in
emergency treatment trials. (4) Explore innovative strategies to increase quality of emergency care data
and to ensure retention of subjects enrolled in emergency settings. The investigators have established
working relationships to conduct clinical trials and are leaders in cardiac and neurological emergencies.
Through experience in prior research networks and investigator initiated research, this site has created
efficient research staffing models, toolkits and telemedicine approaches to emergency informed consent,
novel mobile health strategies for subject retention, special skill with prehospital electronic data, and unique
integration of critical care and emergency medicine. These efficiencies and innovations will be shared and
are scalable for SIREN.

## Key facts

- **NIH application ID:** 9963418
- **Project number:** 5U24NS100656-04
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Clifton W. Callaway
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $148,796
- **Award type:** 5
- **Project period:** 2017-07-15 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9963418

## Citation

> US National Institutes of Health, RePORTER application 9963418, Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) - Pittsburgh (5U24NS100656-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9963418. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*