# Somatic TET2 mutations in cardiac remodeling

> **NIH NIH R01** · UNIVERSITY OF VIRGINIA · 2020 · $638,816

## Abstract

ABSTRACT
The accumulation of somatic DNA mutations over time is a hallmark of aging in many tissues. However, the
causal role of somatic mutations in age-associated disorders other than cancer is a matter of debate, and
remains unexplored in the setting of cardiovascular disease (CVD), the leading cause of death in elderly
individuals. Recent large exome sequencing studies in humans have shown that aging is inevitably associated
with an increased frequency of somatic mutations in the hematopoietic system, which provide a competitive
growth advantage to the mutant cell and thus allow its clonal expansion (clonal hematopoiesis). Unexpectedly,
these somatic mutations were associated with a higher rate of cardiovascular-related deaths,
suggesting a previously unrecognized link between somatic
mutations in bone marrow-derived cells
and CVD
. However, whether there is a causal connection between these somatic mutations and CVD remains
unclear and the potential underlying mechanisms are completely unknown, and this is the scientific premise of
the proposed research.

## Key facts

- **NIH application ID:** 9964526
- **Project number:** 5R01HL138014-05
- **Recipient organization:** UNIVERSITY OF VIRGINIA
- **Principal Investigator:** KENNETH WALSH
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $638,816
- **Award type:** 5
- **Project period:** 2017-07-15 → 2021-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9964526

## Citation

> US National Institutes of Health, RePORTER application 9964526, Somatic TET2 mutations in cardiac remodeling (5R01HL138014-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9964526. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*