# Preclinical Discovery Core

> **NIH NIH P30** · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $162,560

## Abstract

Preclinical studies aimed at elucidating the mechanism of action or establishing the proof-of-concept of
function promoting therapies (FPTs) in animal models are predicated critically upon the ability to measure the
effects of FPTs on whole body and regional skeletal muscle mass and quality, muscle mechanics and
performance, energetics, blood flow, and physical function. Based upon surveys of core users, and in
consultation with OAIC's Advisory Board, the Executive Committee established a Small Animal Resource Core
(SARC) in year 3 of OAIC's first cycle. Additional feedback from the SARC users led to the recognition that the
physician scientists, especially geriatricians with limited experience with laboratory animals, needed substantial
guidance in the selection of appropriate animal model, genetic model identification, outcome selection,
experimental design and the execution of FPT studies. Accordingly, the consultative role of the SARC core
was expanded and the core was re-named the Preclinical Discovery Core (PDC).
In its initial brief funding cycle, the PDC supported 3 PES projects, 2 REC project, and 7 external projects. The
studies utilizing the PDC infrastructure have resulted in 17 peer-reviewed publications, including several high-
impact publications in leading journals including PNAS (2 papers), Cell Metabolism (1 paper), Blood (1 paper),
Diabetes (1 paper), and Aging Cell (2 papers), and $8.42 million dollars in grant funding.
The specific aims of the PDC are to provide the infrastructure, consultative support, and standardized methods
to assess whole body and regional skeletal muscle and fat mass, muscle performance and energetics,
metabolic outcomes, and physical function in preclinical models of aging and illness. The PDC will develop
novel non-invasive imaging methods to measure myofibrillar space, perfusion, energetics, and regeneration in
preclinical models of FPT action. The PDC will implement rigorous quality control by personnel training and
certification in standardized procedures for assessment of muscle performance and physical function, and by
maintaining equipment calibration.
The developmental project (DP3) will develop an innovative non-invasive method for quantitative assessment
of myofibrillar space, muscle perfusion, energetics, and muscle oxygen uptake, using 7 Tesla magnetic
resonance imaging and spectroscopy. The PDC has introduced several innovations, including: integration of
new T1 and T2 sequences for improved precision of body composition assessment by NMR; coupling of core
body thermogenics with energy expenditure assessment; integration of high sensitivity motor electronics to
improve the precision and accuracy of ex-vivo strength measurements; and improving the precision of grip
strength measurements. The highly specialized services and expertise offered by PDC is unique among
OAICs, and central to the successful execution of several external and OAIC projects.

## Key facts

- **NIH application ID:** 9964640
- **Project number:** 5P30AG031679-10
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** Ravi Jasuja
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $162,560
- **Award type:** 5
- **Project period:** — → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9964640

## Citation

> US National Institutes of Health, RePORTER application 9964640, Preclinical Discovery Core (5P30AG031679-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9964640. Licensed CC0.

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