# Biostatistics Data Analysis Core

> **NIH NIH P30** · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $203,184

## Abstract

The Biostatistical Design and Analysis Core (BDAC) was established in year 3 of the first funding cycle in
response to user surveys which expressed a strong need for sound and efficient biostatistical expertise and
resource support. The overall aims of BDAC are to provide data management and biostatistical resources and
expertise to promote best statistical practices; and to facilitate the development of function-promoting therapies
through research and the training of biomedical and data scientists committed to aging research. BDAC
activities are directed toward the three mutually reinforcing Specific Aims: (1) To provide rigorous, secure and
comprehensive biostatistical and data management support to OAIC projects. (2) To conduct novel applied
and methodologic research aligned with the OAIC initiatives, with emphasis on conduct of intervention trials
and translational research in FPTs. (3) To insure rigorous training in research design and data analysis of
clinical and quantitative scientists, with emphasis on the epidemiology and treatment of loss of physical
function in aging.
 The BDAC's outstanding leadership has substantial expertise in clinical trials, observational studies,
experimental design, multivariate analysis, causal inference, statistical genetics, graphical data display, and
missing data, and is seasoned in the leadership of data science teams. The Core is led by Thomas Travison,
PhD (Core Leader), a biostatistician and translational researcher with 15 years' experience in the design and
analysis of clinical studies in aging; and Ralph D'Agostino, PhD (Core Co-Leader), an internationally
recognized leader in clinical trials design, observational studies, and comparative effectiveness research; and
Paola Sebastiani, Ph.D., an internationally recognized statistical geneticist.
 Core personnel maintain active and highly productive collaborative relationships with OAIC biomedical
investigators, as well as leadership in independent and collaborative research programs with allied scientists.
In addition, the BDAC provides key venues for dynamic mentoring, collaboration and peer support for OAIC
investigators and trainees through its interactive methods workshop and seminar series, consultative services,
and the continual interaction between Core personnel and OAIC-affiliated scientists and physicians. The
BDAC has embedded continuous innovation in its operations; examples of this innovation include the novel
risk scoring algorithms developed by the BDAC biostatisticians for mobility disability and cardiometabolic
illnesses in older populations; collaborative work with OAIC-affiliated biostatisticians at Yale and Wake Forest
universities in designing novel randomization schemes for pragmatic cluster-randomized trials; and the
development of novel and integrated web-enabled tools in the developmental project, which enhance the
replicability and reproducibility of scientific findings. The BDAC is therefore a key contributor to the Boston...

## Key facts

- **NIH application ID:** 9964644
- **Project number:** 5P30AG031679-10
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** Thomas Glenn Travison
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $203,184
- **Award type:** 5
- **Project period:** — → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9964644

## Citation

> US National Institutes of Health, RePORTER application 9964644, Biostatistics Data Analysis Core (5P30AG031679-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9964644. Licensed CC0.

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