# Role of Prophage in S. pyogenes Gene regulatation

> **NIH NIH R03** · UNIVERSITY OF SOUTH DAKOTA · 2020 · $73,500

## Abstract

Streptococcus pyogenes is a leading bacterial cause of human morbidity and
mortality. Virulence correlates with the expression of a variety of toxins and other
proteins, many of which are regulated by the transcriptional regulator Rgg1; one of four
Rgg paralogues in the S. pyogenes chromosome. The Rgg1 regulon varies among
clinical isolates, which differ primarily in the number and types of prophages and other
horizontally transmitted elements present in chromosome. The overall hypothesis of the
project is that Rgg1 interacts with specific prophage DNA to influence genomewide
patterns of expression and create phenotypic diversity within the species. Such
diversity is likely reflected in the wide variety of clinical manifestations associated with
the pathogen. The hypothesis will be tested by characterizing Rgg1-mediated gene
regulation using a genetic derivative isolate that lacks a single chromosomal island.

## Key facts

- **NIH application ID:** 9964658
- **Project number:** 5R03AI142593-02
- **Recipient organization:** UNIVERSITY OF SOUTH DAKOTA
- **Principal Investigator:** MICHAEL S CHAUSSEE
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $73,500
- **Award type:** 5
- **Project period:** 2019-06-26 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9964658

## Citation

> US National Institutes of Health, RePORTER application 9964658, Role of Prophage in S. pyogenes Gene regulatation (5R03AI142593-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9964658. Licensed CC0.

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