# Animal Breeding Core

> **NIH NIH P50** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2020 · $179,944

## Abstract

.
ABSTRACT
As all Center components will use genetically engineered mice, a central Animal Breeding Core (AB-Core) will
be used to meet the animal needs of all Center Projects and Pilots and provide cost-effective, uniformly bred
and monitored use of CSORDA animals. Additionally, the Core is a resource, particularly for mice which are
mutant in opioid-genes, for providing animals for Pilots and research outside of CSORDA at UCLA, as well as
many other institutions. The AB-Core was established in 2006 and developed a set of standardized
procedures to accomplish this goal.
The functions of the AB-Core are as follows:
1. The AB-Core will coordinate with each Project, Pilot and the TA-Core to provide the required cohorts of
 male and female mice as needed. Planning, prioritization and sharing of animal breeding will be an
 agenda item at Steering Committee meetings.
2. The AB-Core will maintain each line under optimal breeding management practices.
3. Since multiple CSORDA research components utilize cross-bred lines, the AB-Core will ensure all lines
 are correctly maintained as congenic on the C57BL/6J background.
4. The AB-Core will follow the correct breeding strategies to ensure wild-type and mutant mice are bred as
littermates.
5. The AB-Core will verify that correct patterns of expression are achieved following cre-mediated deletion
 in both males and females.
6. The AB-Core will coordinate mouse sharing, with a major role of the transfer of breeding pairs between
 CSORDA performance sites at UCLA and Dr. Kieffer at the Douglas Institute in Montreal.

## Key facts

- **NIH application ID:** 9964744
- **Project number:** 5P50DA005010-34
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** WENDY M WALWYN
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $179,944
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9964744

## Citation

> US National Institutes of Health, RePORTER application 9964744, Animal Breeding Core (5P50DA005010-34). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9964744. Licensed CC0.

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