# Targeted ROS releasing PEG-Fibrin composite adhesive-hydrogel to control matrix modulation as a wound healing and tissue engineering support

> **NIH NIH R15** · MICHIGAN TECHNOLOGICAL UNIVERSITY · 2020 · $400,343

## Abstract

PROJECT SUMMARY
This proposal addresses several existing challenges in developing better control systems for therapeutic tissue
engineering including: 1) minimizing infection associated with delivered biomaterials/devices; 2) creating in-situ
curable material with a suitable environment for local cell migration, stable cell delivery and promotion of injury
repair; 3) establishing a stable adhesive interface between a tissue engineered construct (hydrogel) and injured
tissues; 4) targeting spatial and temporal release of multifunctional dose dependent reactive oxygen species
(ROS). The ROS releasing composite adhesive-hydrogels and focused ultrasound (FUS) delivery system being
developed in this proposal addresses these challenges. The primary innovative component is the possible use
of FUS to spatially and temporally target ROS release as a regenerative tissue support that not only aids in
stabilizing the matrix metabolic activity of the regenerative site but also provides secondary support through its
innate antimicrobial character. The main objectives of this proposal are: 1) create a library of composite hydrogel
formulations with controlled ROS release profiles as well as physical and adhesive properties; 2) build a custom
FUS therapy system and characterize its ability modulate formulations in real-time to target wound healing and
prevent infection in vitro; 3) verify candidate formulations promote wound healing in an Achilles tendon defect
model.

## Key facts

- **NIH application ID:** 9965158
- **Project number:** 1R15GM137298-01
- **Recipient organization:** MICHIGAN TECHNOLOGICAL UNIVERSITY
- **Principal Investigator:** Smitha Rao Hatti
- **Activity code:** R15 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $400,343
- **Award type:** 1
- **Project period:** 2020-05-01 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9965158

## Citation

> US National Institutes of Health, RePORTER application 9965158, Targeted ROS releasing PEG-Fibrin composite adhesive-hydrogel to control matrix modulation as a wound healing and tissue engineering support (1R15GM137298-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9965158. Licensed CC0.

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