# Mid-Career Mentoring Award for Patient-Oriented Research in Aging

> **NIH NIH K24** · BETH ISRAEL DEACONESS MEDICAL CENTER · 2020 · $179,615

## Abstract

PROJECT SUMMARY/ABSTRACT:
My patient-oriented research (POR) program addresses knowledge gaps and barriers to care of hospitalized
older adults with delirium. I seek renewal of my National Institute on Aging (NIA) K24 Award to continue to
effectively leverage my ongoing research to mentor new investigators in aging research. My Aims are:
Aim 1. To continue to conduct high quality POR research that will translate into improved care for hospitalized
older adults with delirium, with an emerging focus on Implementation Science. This will be accomplished
through my ongoing funded projects, and a newly funded R01 that moves toward implementation.
Current Research: Much of my current research seeks a better understanding of delirium pathophysiology, with
a goal of developing new biomarkers that could lead to improved diagnosis, monitoring, prognostication and
the development of targeted therapies. My major project “Biomarker Discovery for Delirium” within the P01
“Interdisciplinary Study of Delirium and Its Long Term Outcomes” identified several new delirium biomarkers,
including cytokines and acute phase reactants. With funding from the R01, “Advancing Understanding of
Postoperative Delirium Mechanisms via Multi-OMICS”, we are validating these protein biomarkers in larger
samples, discovering new lipid and metabolite biomarkers, and examining cerebrospinal fluid.
New Research: My new research seeks to implement efficient, straightforward tools for delirium identification in
hospitalized elders. My recently completed R01, “3D-CAM: Deriving and Validating a 3-minute Diagnostic
Assessment for Delirium” developed and validated a high performing short diagnostic tool for delirium, the 3D-
CAM, and identified ultra-brief screening tools. My newly funded R01: “READI: Researching Efficient
Approaches to Delirium Identification”, aims to test these tools in the hands of clinicians, and to assess barriers
and facilitators to implementation. The long term of goal of this research is to implement routine assessment of
delirium into care of hospitalized older adults, improving diagnosis, monitoring, and prognostication.
Aim 2: To continue to use my research as a platform to mentor new POR investigators in delirium research,
and to help them become independent investigators. This will support both the expansion of my research
program and the field of delirium research. This aim will be accomplished by: i. direct involvement of my
trainees in my ongoing projects, ii. leveraging my programmatic research infrastructure to enable my mentees'
investigations, and iii. ongoing recruitment of high caliber mentees to my research and mentoring program.
Impact: Despite steady progress in delirium research over the past 25 years, much of the advances in this
field have failed to reach the bedside of vulnerable hospitalized older adults. The focus of my ongoing projects
and newly funded research, my proposed career development activities in Implementation Science, and my
ongoing...

## Key facts

- **NIH application ID:** 9965702
- **Project number:** 5K24AG035075-09
- **Recipient organization:** BETH ISRAEL DEACONESS MEDICAL CENTER
- **Principal Investigator:** EDWARD R MARCANTONIO
- **Activity code:** K24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $179,615
- **Award type:** 5
- **Project period:** 2010-09-30 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9965702

## Citation

> US National Institutes of Health, RePORTER application 9965702, Mid-Career Mentoring Award for Patient-Oriented Research in Aging (5K24AG035075-09). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9965702. Licensed CC0.

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