# Testing the Effectiveness of Individualized Disease Prevention for Middle-Aged Adults

> **NIH NIH R01** · CLEVELAND CLINIC LERNER COM-CWRU · 2020 · $577,056

## Abstract

Project Summary/Abstract
This proposal seeks to help middle-aged adults (aged 50-64 y) make an informed decision about the health
care services that are most likely to promote a longer, healthier life. There are currently 26 evidence-based
services to prevent or manage chronic disease in middle-age, but it is difficult to follow them all. Patients need
help to better understand the tradeoffs between services.
To overcome these barriers, we are currently conducting an R21 that identifies the preventive services with the
greatest impact on life expectancy, and engages patients and providers in shared decision-making. Patients
and providers highly value the framework. We also are developing proof-of-concept to access and print the
results in the electronic health record.
This proposal has 3 aims. First, we will adapt a previously-published analytic model to measure the gain in
quality-adjusted life expectancy associated with adherence to 24 of 26 major preventive care services. Results
will be individualized for a patient’s age and risk factors. Second, we will integrate a previously-developed
decision aid with the electronic health record. We will conduct iterative testing to ensure accuracy and
usefulness. Third, we will conduct a randomized trial to test the effectiveness of the decision aid on middle-
aged patient behavior in diverse primary care clinics. During clinical visits, patients and physicians will discuss
the decision aid and engage in shared decision making, to prioritize preventive care goals. We will measure
the change in preventive care utilization between intervention and control patients.
This proposal builds upon our inter-disciplinary team’s strong foundation in clinical research, mathematical
modeling, shared decision-making and information technology. A successful intervention should help to
fundamentally change preventive care delivery in the United States, to maximize health and prevent illness in
the middle-aged population.

## Key facts

- **NIH application ID:** 9965716
- **Project number:** 5R01AG059979-02
- **Recipient organization:** CLEVELAND CLINIC LERNER COM-CWRU
- **Principal Investigator:** Glen Taksler
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $577,056
- **Award type:** 5
- **Project period:** 2019-07-01 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9965716

## Citation

> US National Institutes of Health, RePORTER application 9965716, Testing the Effectiveness of Individualized Disease Prevention for Middle-Aged Adults (5R01AG059979-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9965716. Licensed CC0.

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