# Predicting rehabilitation outcomes in bilingual aphasia using computational modeling

> **NIH NIH U01** · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · 2020 · $605,305

## Abstract

Bilingualism is an exponentially increasing trend in today's world population due to mass immigration and
globalization. Nonetheless, there are no guidelines for the optimal rehabilitation for bilingual patients with
aphasia, and this poses a great challenge to reducing health disparities. One of NIDCD's Health Disparities
2009-2013 Strategic Research Plan includes a goal to better treat aphasia in bilingual individuals
(http://www.nidcd.nih.gov/about/plans/strategic/pages/FY2009-13-HDplan.aspx). The current research on this
topic, however, lacks specific recommendations on which languages should be trained in a bilingual aphasic
individual and to what extent cross-language transfer occurs subsequent to rehabilitation. Factors contributing
to the paucity of research in this area relate to the multitude of possible language combinations in a bilingual
individual, the relative competency of the two languages of the bilingual individual and the effect of focal brain
damage on bilingual language representation. It is, however, unfeasible to examine these issues without
undertaking a large scale longitudinal study in this population.
As a potential solution, in our previous work, we developed a computational model to simulate language
recovery following rehabilitation in bilingual aphasia. Specifically, we trained, lesioned, and retrained a bilingual
computational model in order to systematically characterize the effect of AoA, pre-stroke language proficiency,
and post-stroke naming output on the rehabilitation outcomes. Results demonstrated that a computational
model including these variables was able to capture the many complex profiles that surface in aphasia both
before and after intervention. In addition, it was able to predict the extent of cross-language generalization.
However, the work of using this model to fully understand bilingual aphasia rehabilitation has just begun. In the
proposed project, we extend this work to now examine the predictive abilities of the model and identify the
factors that can maximize cross-language generalization. We also extend the architecture and functionality of
this model, which was originally developed to simulate Spanish-English bilingual language processing, to
Chinese-English which is another language combination commonly encountered in the US and has a strong
theoretical and experimental foundation in computational modeling.
The proposed work is innovative, because it uses a computational model to predict optimal rehabilitation
protocols to facilitate the greatest amount of language recovery in bilingual aphasia. The successful completion
of this project is expected to have an important impact on rehabilitation of stroke and bilingual aphasia as well
as on the applications of computational modeling.

## Key facts

- **NIH application ID:** 9965895
- **Project number:** 5U01DC014922-05
- **Recipient organization:** BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
- **Principal Investigator:** Swathi Kiran
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $605,305
- **Award type:** 5
- **Project period:** 2016-07-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9965895

## Citation

> US National Institutes of Health, RePORTER application 9965895, Predicting rehabilitation outcomes in bilingual aphasia using computational modeling (5U01DC014922-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9965895. Licensed CC0.

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