# Experimental Core

> **NIH NIH U2C** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2020 · $334,800

## Abstract

Project Summary – Experimental Core
The Experimental Core at the West Coast Metabolomics Center for Compound Identification (WCMC) is
committed to the overall goals of the NIH Common Fund Metabolomics Initiative and specifically aims to greatly
improve small molecule identifications. The Experimental Core is led by the WCMC director Prof. Fiehn with
close support from several experienced mass spectrometrists, chromatography experts and database
programmers. The following specific aims will be covered: 1) The use of deuterium exchange, specific functional
group derivatization and high resolution chromatography/mass spectrometry to deduce substructural features to
drastically limit the number of false isomers. The information will be incorporated into a compound identification
pipeline and software tools developed in close collaboration with the Computational Core. 2) The development
of a large open access reference library for LC-MS/MS and GC-MS retention times and mass spectral data.
These databases serve as backbone for our LC-BinBase database that will employ high quality MS/MS spectra
through our MS-DIAL software and link it to biomedical metadata through our miniX study design database. Such
information will be used for the detection of presence and intensity of unknowns that can be prioritized using
BinVestigate across a large diversity of biological studies. 3) The experimental validation of computational
methods and confirmation of novel metabolites, the benchmark of WCMC and consortium capabilities and
acquisition of data through suitable metabolomic reference studies and blinded sets of chemical standards.

## Key facts

- **NIH application ID:** 9965948
- **Project number:** 5U2CES030158-03
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Oliver Fiehn
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $334,800
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9965948

## Citation

> US National Institutes of Health, RePORTER application 9965948, Experimental Core (5U2CES030158-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9965948. Licensed CC0.

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