# Hematopoietic Bone Marrow Microenvironment in Aging and Age-related Leukemia

> **NIH NIH P20** · RHODE ISLAND HOSPITAL · 2020 · $217,783

## Abstract

Project Summary/Abstract:
 The increasing number of elderly people affected by age-related blood malignancies, mainly of the
myeloid subtype, is one of the most significant public health challenges today but currently there are no
effective treatments. The overall objective of this project is to investigate the role of bone marrow
microenvironment in hematopoiesis and age-related leukemia. We previously discovered that deficiency of the
lipid phosphatase SHIP enables long-term reconstitution of the hematopoietic bone marrow microenvironment.
This proposed study is a continuation of our prior work. We will investigate the role of aged bone marrow
microenvironment in normal hematopoiesis (Aim 1), identify and functionally evaluate critical cell types for the
hematopoietic niche (Aim 2), and reconstitute aged and pre-leukemic bone marrow microenvironment via SHIP
inhibition in vivo (Aim 3). The long-term goal of this project is to develop novel strategies for treatment of
deadly blood diseases such as myelodysplastic syndromes, myeloproliferative neoplasms, myelofibrosis and
acute myeloid leukemia in elderly people.

## Key facts

- **NIH application ID:** 9965982
- **Project number:** 5P20GM119943-04
- **Recipient organization:** RHODE ISLAND HOSPITAL
- **Principal Investigator:** Olin D. Liang
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $217,783
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9965982

## Citation

> US National Institutes of Health, RePORTER application 9965982, Hematopoietic Bone Marrow Microenvironment in Aging and Age-related Leukemia (5P20GM119943-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9965982. Licensed CC0.

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