# Kansas City - New Vaccine Surveillance Network (KC-NVSN)

> **NIH ALLCDC U01** · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · 2020 · $1,505,484

## Abstract

Project Summary:
The Kansas City-New Vaccine Surveillance Network (KC-NVSN) program was established in 2009 to conduct
population-based, laboratory-confirmed, active surveillance of acute gastroenteritis (AGE) illness in children
seeking care at Children's Mercy Hospital, in Kansas City (KC), MO. The program was subsequently expanded
in 2015 to include hospitalized ARI children in inpatient (IP) settings.
In the current proposal, the KC-NVSN program seeks to continue the existing pediatric AGE IP and outpatient
(OP) surveillance in the six county KC metropolitan area and ARI IP surveillance in Jackson County, MO. In
addition, we will expand ARI surveillance to OP from Jackson County visiting the main CMH emergency
department. Age and time matched healthy control children will also be enrolled. Eligible children visiting or
admitted to our hospital system as defined above will be enrolled using permission and assent forms approved
by the institutional review board (IRB) of CMH. We will conduct parent interviews, collect medical chart data
and retrieve hard copies of vaccine information for influenza and rotavirus from enrolled children. Clinical
specimens collected from children will be tested for rotavirus (and other GI pathogens, e.g. norovirus in
proposed subprojects) in stool and 22 respiratory pathogens from respiratory specimen including specific
influenza subtypes and other non-influenza viruses, such as RSV, EV-D68 etc. The data collected from the
KC-NVSN program will provide population-based estimates to address the following specific aims:
1. To assess vaccine effectiveness (VE) in preventing medically attended rotavirus and influenza
 illness by the test-negative case-control study design using laboratory confirmed testing among
 enrolled children.
2. To assess the burden of select AGE pathogens and non-influenza viral pathogens, including
 respiratory syncytial virus and EV-D68 among enrolled children.
The KC-NVSN program will provide data to be combined with other geographically diverse sites to estimate the
national incidence, burden, and etiology of community-acquired AGE and ARI. The VE for rotavirus and
seasonal influenza vaccinations will be calculated to measure the impact of vaccination. This network will also
address several important scientific questions related to natural history of pediatric infectious diseases,
transmission dynamics, impact of vaccine on targeted and vulnerable population and factors that influence
vaccine effectiveness. The surveillance data generated from this network will provide timely and highly useful
data to inform public health measures and pediatric vaccine-related policies aimed at controlling AGE and ARI
in US children.

## Key facts

- **NIH application ID:** 9966828
- **Project number:** 5U01IP001057-05
- **Recipient organization:** CHILDREN'S MERCY HOSP (KANSAS CITY, MO)
- **Principal Investigator:** Christopher Harrison
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** ALLCDC
- **Fiscal year:** 2020
- **Award amount:** $1,505,484
- **Award type:** 5
- **Project period:** 2016-09-01 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9966828

## Citation

> US National Institutes of Health, RePORTER application 9966828, Kansas City - New Vaccine Surveillance Network (KC-NVSN) (5U01IP001057-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9966828. Licensed CC0.

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